Atomic force microscopy study of erythrocyte shape and membrane structure after treatment with a dihydropyridinic drug

M Girasole; A Cricenti; R Generosi; A Congiu Castellano; F Boffi; Alessandro Arcovito; G Boumis; G. Amiconi

doi:10.1063/1.126736

Atomic force microscopy study of erythrocyte shape and membrane structure after treatment with a dihydropyridinic drug

M Girasole, A Cricenti, R Generosi, A Congiu Castellano, F Boffi, Alessandro Arcovito, G Boumis, G. Amiconi

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

10 Citazioni (Scopus)

Abstract

The overall shape and membrane surface of human erythrocytes (RBCs) in the presence of nifedipine (a dihydropyridinic drug used in the clinical treatment of hypertension and angina pectoris) were imaged by contact-mode atomic force microscopy. Nifedipine induces in RBCs relevant morphological changes the extent of which increases as a function of drug concentration and incubation time. The modifications have been interpreted as mainly due to insertion of nifedipine into the outer layer of the RBC membrane. The potential effect of nifedipine as a hemoglobin denaturant has been ruled out by x-ray absorption near-edge structure and optical spectroscopies. (C) 2000 American Institute of Physics. [S0003-6951(00)01024-X].

Lingua originale	English
pagine (da-a)	3650-3652
Numero di pagine	3
Rivista	Applied Physics Letters
Volume	76
DOI	https://doi.org/10.1063/1.126736
Stato di pubblicazione	Pubblicato - 2000

Keywords

AFM
Nifedipin

Accesso al documento

10.1063/1.126736

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title = "Atomic force microscopy study of erythrocyte shape and membrane structure after treatment with a dihydropyridinic drug",

abstract = "The overall shape and membrane surface of human erythrocytes (RBCs) in the presence of nifedipine (a dihydropyridinic drug used in the clinical treatment of hypertension and angina pectoris) were imaged by contact-mode atomic force microscopy. Nifedipine induces in RBCs relevant morphological changes the extent of which increases as a function of drug concentration and incubation time. The modifications have been interpreted as mainly due to insertion of nifedipine into the outer layer of the RBC membrane. The potential effect of nifedipine as a hemoglobin denaturant has been ruled out by x-ray absorption near-edge structure and optical spectroscopies. (C) 2000 American Institute of Physics. [S0003-6951(00)01024-X].",

keywords = "AFM, Nifedipin, AFM, Nifedipin",

author = "M Girasole and A Cricenti and R Generosi and {Congiu Castellano}, A and F Boffi and Alessandro Arcovito and G Boumis and G. Amiconi",

year = "2000",

doi = "10.1063/1.126736",

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TY - JOUR

T1 - Atomic force microscopy study of erythrocyte shape and membrane structure after treatment with a dihydropyridinic drug

AU - Girasole, M

AU - Cricenti, A

AU - Generosi, R

AU - Congiu Castellano, A

AU - Boffi, F

AU - Arcovito, Alessandro

AU - Boumis, G

AU - Amiconi, G.

PY - 2000

Y1 - 2000

N2 - The overall shape and membrane surface of human erythrocytes (RBCs) in the presence of nifedipine (a dihydropyridinic drug used in the clinical treatment of hypertension and angina pectoris) were imaged by contact-mode atomic force microscopy. Nifedipine induces in RBCs relevant morphological changes the extent of which increases as a function of drug concentration and incubation time. The modifications have been interpreted as mainly due to insertion of nifedipine into the outer layer of the RBC membrane. The potential effect of nifedipine as a hemoglobin denaturant has been ruled out by x-ray absorption near-edge structure and optical spectroscopies. (C) 2000 American Institute of Physics. [S0003-6951(00)01024-X].

AB - The overall shape and membrane surface of human erythrocytes (RBCs) in the presence of nifedipine (a dihydropyridinic drug used in the clinical treatment of hypertension and angina pectoris) were imaged by contact-mode atomic force microscopy. Nifedipine induces in RBCs relevant morphological changes the extent of which increases as a function of drug concentration and incubation time. The modifications have been interpreted as mainly due to insertion of nifedipine into the outer layer of the RBC membrane. The potential effect of nifedipine as a hemoglobin denaturant has been ruled out by x-ray absorption near-edge structure and optical spectroscopies. (C) 2000 American Institute of Physics. [S0003-6951(00)01024-X].

KW - AFM

KW - Nifedipin

KW - AFM

KW - Nifedipin

UR - http://hdl.handle.net/10807/11825

UR - http://dx.medra.org/10.1063/1.126736

U2 - 10.1063/1.126736

DO - 10.1063/1.126736

M3 - Article

SN - 0003-6951

VL - 76

SP - 3650

EP - 3652

JO - Applied Physics Letters

JF - Applied Physics Letters

ER -

Atomic force microscopy study of erythrocyte shape and membrane structure after treatment with a dihydropyridinic drug

Abstract

Keywords

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