TY - JOUR
T1 - Associations between DSM-IV mental disorders and subsequent COPD diagnosis
AU - Rapsey, Charlene M.
AU - Lim, Carmen C.W.
AU - Al-Hamzawi, Ali
AU - Alonso, Jordi
AU - Bruffaerts, Ronny
AU - Caldas-De-Almeida, J. M.
AU - Florescu, Silvia
AU - De Girolamo, Giovanni
AU - Hu, Chiyi
AU - Kessler, Ronald C.
AU - Kovess-Masfety, Viviane
AU - Levinson, Daphna
AU - Medina-Mora, María Elena
AU - Murphy, Sam
AU - Ono, Yutaka
AU - Piazza, Maria
AU - Posada-Villa, Jose
AU - Ten Have, Margreet
AU - Wojtyniak, Bogdan
AU - Scott, Kate M.
PY - 2015
Y1 - 2015
N2 - Abstract
OBJECTIVES:
COPD and mental disorder comorbidity is commonly reported, although findings are limited by substantive weaknesses. Moreover, few studies investigate mental disorder as a risk for COPD onset. This research aims to investigate associations between current (12-month) DSM-IV mental disorders and COPD, associations between temporally prior mental disorders and subsequent COPD diagnosis, and cumulative effect of multiple mental disorders.
METHODS:
Data were collected using population surveys of 19 countries (n=52,095). COPD diagnosis was assessed by self-report of physician's diagnosis. The World Mental Health-Composite International Diagnostic Interview (WMH-CIDI) was used to retrospectively assess lifetime prevalence and age at onset of 16 DSM-IV disorders. Adjusting for age, gender, smoking, education, and country, survival analysis estimated associations between first onset of mental disorder and subsequent COPD diagnosis.
RESULTS:
COPD and several mental disorders were concurrently associated across the 12-month period (ORs 1.5-3.8). When examining associations between temporally prior disorders and COPD, all but two mental disorders were associated with COPD diagnosis (ORs 1.7-3.5). After comorbidity adjustment, depression, generalized anxiety disorder, and alcohol abuse were significantly associated with COPD (ORs 1.6-1.8). There was a substantive cumulative risk of COPD diagnosis following multiple mental disorders experienced over the lifetime.
CONCLUSIONS:
Mental disorder prevalence is higher in those with COPD than those without COPD. Over time, mental disorders are associated with subsequent diagnosis of COPD; further, the risk is cumulative for multiple diagnoses. Attention should be given to the role of mental disorders in the pathogenesis of COPD using prospective study designs.
AB - Abstract
OBJECTIVES:
COPD and mental disorder comorbidity is commonly reported, although findings are limited by substantive weaknesses. Moreover, few studies investigate mental disorder as a risk for COPD onset. This research aims to investigate associations between current (12-month) DSM-IV mental disorders and COPD, associations between temporally prior mental disorders and subsequent COPD diagnosis, and cumulative effect of multiple mental disorders.
METHODS:
Data were collected using population surveys of 19 countries (n=52,095). COPD diagnosis was assessed by self-report of physician's diagnosis. The World Mental Health-Composite International Diagnostic Interview (WMH-CIDI) was used to retrospectively assess lifetime prevalence and age at onset of 16 DSM-IV disorders. Adjusting for age, gender, smoking, education, and country, survival analysis estimated associations between first onset of mental disorder and subsequent COPD diagnosis.
RESULTS:
COPD and several mental disorders were concurrently associated across the 12-month period (ORs 1.5-3.8). When examining associations between temporally prior disorders and COPD, all but two mental disorders were associated with COPD diagnosis (ORs 1.7-3.5). After comorbidity adjustment, depression, generalized anxiety disorder, and alcohol abuse were significantly associated with COPD (ORs 1.6-1.8). There was a substantive cumulative risk of COPD diagnosis following multiple mental disorders experienced over the lifetime.
CONCLUSIONS:
Mental disorder prevalence is higher in those with COPD than those without COPD. Over time, mental disorders are associated with subsequent diagnosis of COPD; further, the risk is cumulative for multiple diagnoses. Attention should be given to the role of mental disorders in the pathogenesis of COPD using prospective study designs.
KW - Alcohol abuse
KW - Anxiety disorders
KW - COPD
KW - Comorbidity
KW - Depression
KW - Alcohol abuse
KW - Anxiety disorders
KW - COPD
KW - Comorbidity
KW - Depression
UR - http://hdl.handle.net/10807/79507
U2 - 10.1016/j.jpsychores.2015.08.005
DO - 10.1016/j.jpsychores.2015.08.005
M3 - Article
SN - 0022-3999
VL - 79
SP - 333
EP - 339
JO - Journal of Psychosomatic Research
JF - Journal of Psychosomatic Research
ER -