Association of the OCTN1/1672T variant with increased risk for colorectal cancer in young individuals and ulcerative colitis patients

Maurizio Martini; Anna Maria Ferrara; Manuela Giachelia; Emiliano Panieri; Katherine Siminovitch; Tommaso Galeotti; Luigi Maria Larocca; Giovambattista Pani

doi:10.1002/ibd.21814

Association of the OCTN1/1672T variant with increased risk for colorectal cancer in young individuals and ulcerative colitis patients

Maurizio Martini
, Anna Maria Ferrara
, Manuela Giachelia
, Emiliano Panieri
, Katherine Siminovitch
, Tommaso Galeotti
, Luigi Maria Larocca
, Giovambattista Pani

University of Toronto

Risultato della ricerca: Contributo in rivista › Articolo

18 Citazioni (Scopus)

Abstract

Ulcerative colitis (UC) is associated with colorectal cancer. Chronic inflammation may also play a role in the pathogenesis of sporadic colorectal cancer (SCC), particularly in younger patients (<55 years). We evaluated whether single nucleotide polymorphisms of the OCTN1 and OCTN2 genes are associated with UC, SCC, and with UC cases with cancer progression (UCCP).

Lingua originale	Inglese
pagine (da-a)	439-448
Numero di pagine	10
Rivista	Inflammatory Bowel Diseases
Volume	18
DOI	https://doi.org/10.1002/ibd.21814
Stato di pubblicazione	Pubblicato - 2012

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Keywords

Caco-2 Cells
Colitis, Ulcerative
OCTN1-2

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10.1002/ibd.21814

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title = "Association of the OCTN1/1672T variant with increased risk for colorectal cancer in young individuals and ulcerative colitis patients",

abstract = "Ulcerative colitis (UC) is associated with colorectal cancer. Chronic inflammation may also play a role in the pathogenesis of sporadic colorectal cancer (SCC), particularly in younger patients (<55 years). We evaluated whether single nucleotide polymorphisms of the OCTN1 and OCTN2 genes are associated with UC, SCC, and with UC cases with cancer progression (UCCP).",

keywords = "Caco-2 Cells, Colitis, Ulcerative, OCTN1-2, Caco-2 Cells, Colitis, Ulcerative, OCTN1-2",

author = "Maurizio Martini and Ferrara, \{Anna Maria\} and Manuela Giachelia and Emiliano Panieri and Katherine Siminovitch and Tommaso Galeotti and Larocca, \{Luigi Maria\} and Giovambattista Pani",

year = "2012",

doi = "10.1002/ibd.21814",

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journal = "Inflammatory Bowel Diseases",

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TY - JOUR

T1 - Association of the OCTN1/1672T variant with increased risk for colorectal cancer in young individuals and ulcerative colitis patients

AU - Martini, Maurizio

AU - Ferrara, Anna Maria

AU - Giachelia, Manuela

AU - Panieri, Emiliano

AU - Siminovitch, Katherine

AU - Galeotti, Tommaso

AU - Larocca, Luigi Maria

AU - Pani, Giovambattista

PY - 2012

Y1 - 2012

N2 - Ulcerative colitis (UC) is associated with colorectal cancer. Chronic inflammation may also play a role in the pathogenesis of sporadic colorectal cancer (SCC), particularly in younger patients (<55 years). We evaluated whether single nucleotide polymorphisms of the OCTN1 and OCTN2 genes are associated with UC, SCC, and with UC cases with cancer progression (UCCP).

AB - Ulcerative colitis (UC) is associated with colorectal cancer. Chronic inflammation may also play a role in the pathogenesis of sporadic colorectal cancer (SCC), particularly in younger patients (<55 years). We evaluated whether single nucleotide polymorphisms of the OCTN1 and OCTN2 genes are associated with UC, SCC, and with UC cases with cancer progression (UCCP).

KW - Caco-2 Cells

KW - Colitis, Ulcerative

KW - OCTN1-2

KW - Caco-2 Cells

KW - Colitis, Ulcerative

KW - OCTN1-2

UR - http://hdl.handle.net/10807/25734

U2 - 10.1002/ibd.21814

DO - 10.1002/ibd.21814

M3 - Article

SN - 1536-4844

VL - 18

SP - 439

EP - 448

JO - Inflammatory Bowel Diseases

JF - Inflammatory Bowel Diseases

ER -

Association of the OCTN1/1672T variant with increased risk for colorectal cancer in young individuals and ulcerative colitis patients

Abstract

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Keywords

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