Association of the OCTN1/1672T variant with increased risk for colorectal cancer in young individuals and ulcerative colitis patients

Maurizio Martini, Luigi Maria Larocca, Giovambattista Pani, Anna Maria Ferrara, Manuela Giachelia, Emiliano Panieri, Tommaso Galeotti, Katherine Siminovitch

Risultato della ricerca: Contributo in rivistaArticolo in rivista

18 Citazioni (Scopus)

Abstract

Ulcerative colitis (UC) is associated with colorectal cancer. Chronic inflammation may also play a role in the pathogenesis of sporadic colorectal cancer (SCC), particularly in younger patients (<55 years). We evaluated whether single nucleotide polymorphisms of the OCTN1 and OCTN2 genes are associated with UC, SCC, and with UC cases with cancer progression (UCCP).
Lingua originaleEnglish
pagine (da-a)439-448
Numero di pagine10
RivistaInflammatory Bowel Diseases
Volume18
DOI
Stato di pubblicazionePubblicato - 2012

Keywords

  • Caco-2 Cells
  • Colitis, Ulcerative
  • OCTN1-2

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