Association of Body Fat With Health-Related Quality of Life and Depression in Nonagenarians: The Mugello Study.

Rosa Liperoti, Graziano Onder, Luca Padua, Silvia Giovannini, Daniele Coraci, Claudia Loreti, Claudio Macchi, Alice Laudisio, Federica Vannetti, Guglielmo Bonaccorsi, Roberta Boni, Chiara Castagnoli, Francesca Cecchi, Francesca Cesari, Francesco Epifani, Roberta Frandi, Betti Giusti, Maria Luisa Eliana Luisi, Rossella Marcucci, Raffaello Molino-LovaAnita Paperini, Lorenzo Razzolini, Francesco Sofi, Nona Turcan, Debora Valecchi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

3 Citazioni (Scopus)

Abstract

OBJECTIVES: The association of body fat with health status and depression in the oldest old is still debated. The aim of this cross-sectional study is to investigate the association of body fat with health-related quality of life and depression in a sample of nonagenarians. DESIGN: Data are from the Mugello study, a community-based project conducted in Italian older adults aged 90 years. SETTING AND PARTICIPANTS: Total body fat was assessed by body impedance assessment. Participants were divided into 3 groups according to gender-specific tertiles of body fat percentage (BF%). Self-perceived mental and physical health status were assessed by the Mental Component Summary (MCS) and the Physical Component Summary (PCS) subscales derived from the 12-item Short Form Health Survey. Lower scores of MCS and PCS indicated poorer mental health and physical health status, respectively. Depressive symptoms were assessed using the 15-item Geriatric Depression Scale, and a score ≥5 was used to identify participants with depression. RESULTS: The mean age of 251 study participants was 92.5 years, and 173 (68.9%) were women. Participants were included in the low (n = 83), medium (n = 83), and high (n = 85) BF% groups. In the whole sample, mean scores at PCS progressively declined with the increasing BF% group (P = .004). This association was stronger in women, although no significant interaction was observed between the gender and BF% group (P = .63). No significant association between BF% and MCS was documented. Medium and high BF% were associated with a significantly higher probability of depression as compared with low BF% [odds ratio (OR) 2.15, 95% confidence interval (CI) 1.04-4.44, and OR 2.15, 95% CI 1.06-4.34, respectively]. This association was stronger in women, although no significant interaction was observed between gender and BF% group (P = .70). CONCLUSIONS AND IMPLICATIONS: High BF% is significantly positively associated with poor health-related quality of life and depression, underpinning the clinical relevance to test BF% in older adults. These associations appear to be stronger in women than in men, highlighting the need to investigate deep inside this gender discrepancy.
Lingua originaleEnglish
pagine (da-a)564-568
Numero di pagine5
RivistaJournal of the American Medical Directors Association
Volume20
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • Body fat percentage
  • depression
  • nonagenarians
  • physical activity

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