TY - JOUR
T1 - Association between taste receptor (TAS) genes and the perception of wine characteristics.
AU - Carrai, Maura
AU - Campa, Daniele
AU - Vodicka, Pavel
AU - Flamini, Riccardo
AU - Martelli, Irene
AU - Slyskova, Jana
AU - Jiraskova, Katerina
AU - Rejhova, Alexandra
AU - Vodenkova, Sona
AU - Canzian, Federico
AU - Bertelli, Alberto
AU - Dalla Vedova, Antonio
AU - Bavaresco, Luigi
AU - Vodickova, Ludmila
AU - Barale, Roberto
PY - 2017
Y1 - 2017
N2 - Several studies have suggested a possible relationship between polymorphic variants of the taste receptors genes and the acceptance, liking and intake of food and beverages. In the last decade investigators have attempted to link the individual ability to taste 6-n-propylthiouracil (PROP) and the sensations, such as astringency and bitterness, elicited by wine or its components, but with contradictory results. We have used the genotype instead of the phenotype (responsiveness to PROP or other tastants), to test the possible relation between genetic variability and the perception of wine characteristic in 528 subjects from Italy and the Czech Republic. We observed several interesting associations, among which the association between several TAS2R38 gene single nucleotide polymorphisms (P = 0.002) and the TAS2R16-rs6466849 polymorphism with wine sourness P = 0.0003). These associations were consistent in both populations, even though the country of origin was an important factor in the two models, thus indicating therefore that genetics alongside cultural factors also play a significant role in the individual liking of wine.
AB - Several studies have suggested a possible relationship between polymorphic variants of the taste receptors genes and the acceptance, liking and intake of food and beverages. In the last decade investigators have attempted to link the individual ability to taste 6-n-propylthiouracil (PROP) and the sensations, such as astringency and bitterness, elicited by wine or its components, but with contradictory results. We have used the genotype instead of the phenotype (responsiveness to PROP or other tastants), to test the possible relation between genetic variability and the perception of wine characteristic in 528 subjects from Italy and the Czech Republic. We observed several interesting associations, among which the association between several TAS2R38 gene single nucleotide polymorphisms (P = 0.002) and the TAS2R16-rs6466849 polymorphism with wine sourness P = 0.0003). These associations were consistent in both populations, even though the country of origin was an important factor in the two models, thus indicating therefore that genetics alongside cultural factors also play a significant role in the individual liking of wine.
KW - single nucleotide polymorphisms
KW - taste receptor genes
KW - wine
KW - single nucleotide polymorphisms
KW - taste receptor genes
KW - wine
UR - http://hdl.handle.net/10807/109538
U2 - 10.1038/s41598-017-08946-3
DO - 10.1038/s41598-017-08946-3
M3 - Article
SN - 2045-2322
SP - 1
EP - 7
JO - Scientific Reports
JF - Scientific Reports
ER -