Association analysis of GRIN2B, encoding N-methyl-D-aspartate receptor 2B subunit, and Alzheimer's disease

Antonio Daniele, Carlo Masullo, Alessandra Bizzarro, Davide Seripa, Maria Giovanna Matera, Marilisa Franceschi, Francesco Paris, Leandro Cascavilla, Monica Rinaldi, Francesco Panza, Vincenzo Solfrizzi, Bruno Dallapiccola, Alberto Pilotto

Risultato della ricerca: Contributo in rivistaArticolo in rivista

15 Citazioni (Scopus)

Abstract

Background: The glutamatergic neurotransmitter systems play a crucial role in memory formation and information processing. Alterations in this system contribute to the manifestation of symptoms in Alzheimer's disease (AD). Glutamate transmits signals via the N-methyl-D-aspartate receptors (NMDARs). Aims: The potential involvement of polymorphisms in the GRIN2B gene, encoding subunit 2B of the NMDA receptor, in the risk for AD was evaluated. Methods: We investigated the 3 single-nucleotide polymorphisms (SNPs) rs1019385, rs1806201 and rs890, i.e. the G-200→T transversion in the 5′UTR, the A2664→G transition in exon 13 and the G5072→T transition in the 3′UTR of the GRIN2B gene, in 222 Caucasian AD patients and 170 healthy Caucasian age-matched controls. Results: No differences were found in the overall distribution of the single-nucleotide polymorphism genotypes between AD patients and healthy controls, even when the analysis was adjusted for sex, age and APOE. As expected from genotype frequencies, no differences were found in the distribution of the estimated allele and haplotype frequencies between AD patients and healthy controls. Conclusion: In this study no significant association between polymorphisms in the GRIN2B gene and AD was observed. Further investigations of polymorphisms in the gene encoding the NMDA receptor 2B subunit in AD patients with different genetic setting are needed to clarify their role in the pathogenesis of AD. Copyright © 2008 S. Karger AG.
Lingua originaleEnglish
pagine (da-a)287-292
Numero di pagine6
RivistaDementia and Geriatric Cognitive Disorders
Volume25
DOI
Stato di pubblicazionePubblicato - 2008

Keywords

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease
  • Alzheimer's disease
  • Brain
  • Case-Control Studies
  • Cross-Sectional Studies
  • DNA Primers
  • Female
  • Glutamate receptor, ionotropic, N-methyl-D-aspartate 2B
  • Humans
  • Male
  • Middle Aged
  • N-methyl-D-aspartate
  • Neuropsychological Tests
  • Receptors, N-Methyl-D-Aspartate
  • Severity of Illness Index
  • Single-nucleotide polymorphism

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