Assessment of sleep disturbance in oral lichen planus and validation of PSQI: A case-control multicenter study from the SIPMO (Italian Society of Oral Pathology and Medicine)

Carlo Lajolo, Daniela Adamo, Elena Calabria, Noemi Coppola, Lorenzo Lo Muzio, Michele Giuliani, Lorenzo Azzi, Vittorio Maurino, Giuseppe Colella, Raffaele Rauso, Lucio Montebugnoli, Davide Bartolomeo Gissi, Mario Gabriele, Marco Nisi, Andrea Sardella, Giovanni Lodi, Elena Maria Varoni, Amerigo Giudice, Alessandro Antonelli, Marco CabrasAlessio Gambino, Paolo Vescovi, Alessandra Majorana, Elena Bardellini, Giuseppina Campisi, Vera Panzarella, Francesco Spadari, Sonia Marino, Monica Pentenero, Samuele Sutera, Matteo Biasotto, Margherita Gobbo, Luca Guarda Nardini, Umberto Romeo, Gianluca Tenore, Rosario Serpico, Alberta Lucchese, Massimo Aria, Agostino Gnasso, Michele Davide Mignogna

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Background: The wellbeing of oral lichen planus patients (OLPs) may be strongly influenced by a poor quality of sleep (QoS) and psychological impairment. The aims were to analyze the prevalence of sleep disturbance, anxiety, and depression in OLPs and to validate the Pittsburgh Sleep Quality Index (PSQI) in OLPs. Methods: Three hundred keratotic OLPs (K-OLPs), 300 with predominant non-keratotic OLP (nK-OLPs), and 300 controls were recruited in 15 Italian universities. The PSQI, Epworth Sleepiness Scale (ESS), Hamilton Rating Scales for Depression and Anxiety (HAM-D and HAM-A), Numeric Rating Scale (NRS), and Total Pain Rating Index (T-PRI) were administered. Results: Oral lichen planus patients had statistically higher scores than the controls in the majority of the PSQI sub-items (p-values < 0.001**). Moreover, OLPs had higher scores in the HAM-D, HAM-A, NRS, and T-PRI (p-values < 0.001**). No differences in the PSQI sub-items’ scores were found between the K-OLPs and nK-OLPs, although nK-OLPs suffered from higher levels of anxiety, depression, and pain (p-values: HAM-A, 0.007**, HAM-D, 0.009**, NRS, <0.001**, T-PRI, <0.001**). The female gender, anxiety, depression (p-value: 0.007**, 0.001**, 0.020*) and the intensity of pain, anxiety, and depression (p-value: 0.006**, <0.001**, 0.014*) were independent predictors of poor sleep (PSQI > 5) in K-OLPs and nK-OLPs, respectively. The PSQI’s validation demonstrated good internal consistency and reliability of both the total and subscale of the PSQI. Conclusions: The OLPs reported an overall impaired QoS, which seemed to be an independent parameter according to the regression analysis. Hence, clinicians should assess QoS in OLPs and treat sleep disturbances in order to improve OLPs management.
Lingua originaleEnglish
pagine (da-a)194-205-205
RivistaJOURNAL OF ORAL PATHOLOGY &amp; MEDICINE
Volume51
DOI
Stato di pubblicazionePubblicato - 2021

Keywords

  • Anxiety
  • Case-Control Studies
  • Depression
  • Female
  • Humans
  • Lichen Planus, Oral
  • Pathology, Oral
  • Reproducibility of Results
  • Sleep
  • Sleep Wake Disorders
  • Surveys and Questionnaires
  • anxiety
  • insomnia
  • mood disturbance
  • oral lichen planus
  • sleep disturbance

Fingerprint

Entra nei temi di ricerca di 'Assessment of sleep disturbance in oral lichen planus and validation of PSQI: A case-control multicenter study from the SIPMO (Italian Society of Oral Pathology and Medicine)'. Insieme formano una fingerprint unica.

Cita questo