TY - JOUR
T1 - Assessment of neurological manifestations in hospitalized patients with COVID-19
AU - Luigetti, Marco
AU - Iorio, Raffaele
AU - Bentivoglio, Anna Rita
AU - Tricoli, Luca
AU - Riso, Vittorio
AU - Marotta, Jessica
AU - Piano, Carla
AU - Primiano, Guido Alessandro
AU - Lo Monaco, Maria Rita
AU - Calabresi, Paolo
AU - Annetta, Maria Giuseppina
AU - Antonelli, Massimo
AU - Biscetti, Federico
AU - Bosello, Silvia Laura
AU - Capristo, Esmeralda
AU - Cianci, Rossella
AU - Damiano, Fernando
AU - Di Giambenedetto, Simona
AU - Flex, Andrea
AU - Franceschi, Francesco
AU - Gaetani, Eleonora
AU - Gambassi, Giovanni
AU - Grieco, Domenico Luca
AU - Ianiro, Gianluca
AU - Liperoti, Rosa
AU - Maiuro, Giuseppe
AU - Marzetti, Emanuele
AU - Miele, Luca
AU - Montalto, Massimo
AU - Montini, Luca
AU - Murri, Rita
AU - Papa, Alfredo
AU - Pecorini, Giovanni
AU - Pola, Roberto
AU - Richeldi, Luca
AU - Rinninella, Emanuele
AU - Sandroni, Claudio
AU - Santoliquido, Angelo
AU - Scaldaferri, Franco
AU - Staiti, Domenico
AU - Tamburrini, Enrica
AU - Vetrugno, Giuseppe
PY - 2020
Y1 - 2020
N2 - Background and purpose: The objective of this study was to assess the neurological manifestations in a series of consecutive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients, comparing their frequency with a population hospitalized in the same period for flu/respiratory symptoms, finally not related to SARS-CoV-2. Methods: Patients with flu/respiratory symptoms admitted to Fondazione Policlinico Gemelli hospital from 14 March 2020 to 20 April 2020 were retrospectively enrolled. The frequency of neurological manifestations of patients with SARS-CoV-2 infection was compared with a control group. Results: In all, 213 patients were found to be positive for SARS-CoV-2, after reverse transcriptase polymerase chain reaction on nasal or throat swabs, whilst 218 patients were found to be negative and were used as a control group. Regarding central nervous system manifestations, in SARS-CoV-2-positive patients a higher frequency of headache, hyposmia and encephalopathy always related to systemic conditions (fever or hypoxia) was observed. Furthermore, muscular involvement was more frequent in SARS-CoV-2 infection. Conclusions: Patients with COVID-19 commonly have neurological manifestations but only hyposmia and muscle involvement seem more frequent compared with other flu diseases.
AB - Background and purpose: The objective of this study was to assess the neurological manifestations in a series of consecutive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients, comparing their frequency with a population hospitalized in the same period for flu/respiratory symptoms, finally not related to SARS-CoV-2. Methods: Patients with flu/respiratory symptoms admitted to Fondazione Policlinico Gemelli hospital from 14 March 2020 to 20 April 2020 were retrospectively enrolled. The frequency of neurological manifestations of patients with SARS-CoV-2 infection was compared with a control group. Results: In all, 213 patients were found to be positive for SARS-CoV-2, after reverse transcriptase polymerase chain reaction on nasal or throat swabs, whilst 218 patients were found to be negative and were used as a control group. Regarding central nervous system manifestations, in SARS-CoV-2-positive patients a higher frequency of headache, hyposmia and encephalopathy always related to systemic conditions (fever or hypoxia) was observed. Furthermore, muscular involvement was more frequent in SARS-CoV-2 infection. Conclusions: Patients with COVID-19 commonly have neurological manifestations but only hyposmia and muscle involvement seem more frequent compared with other flu diseases.
KW - COVID-19
KW - SARS-CoV-2
KW - muscle
KW - neurological disorders
KW - precision medicine
KW - COVID-19
KW - SARS-CoV-2
KW - muscle
KW - neurological disorders
KW - precision medicine
UR - http://hdl.handle.net/10807/161982
U2 - 10.1111/ene.14444
DO - 10.1111/ene.14444
M3 - Article
SN - 1351-5101
VL - 27
SP - 2322
EP - 2328
JO - European Journal of Neurology
JF - European Journal of Neurology
ER -