Abstract
OBJECTIVE:
To develop and validate a specific simple measure of insulin sensitivity using oral glucose tolerance test (OGTT) values for lean polycystic ovary syndrome (PCOS) women.
DESIGN:
Retrospective study.
SETTING:
Gynecologic Outpatient Clinic of University Hospital, affiliated with Unit of Gynecologic Endocrinology.
PATIENT(S):
Totals of 201 lean and 198 overweight/obese (ov-ob) nondiabetic PCOS patients were retrospectively selected.
INTERVENTION(S):
None.
MAIN OUTCOME MEASURE(S):
All patients underwent OGTT, euglycemic-hyperinsulinemic clamp, and androgenic and biochemical assays. The predictive performance of each insulin resistance (IR) index was analyzed with the use of receiver operating characteristic (ROC) curves.
RESULT(S):
Higher correlation coefficients with clamp studies were obtained with the Belfiore Area (RS=0.579) and the homeostasis-model assessment (HOMA)-M120 (RS=-0.576) in lean PCOS patients and with the Sib (RS=0.697) in ov-ob PCOS patients. The best predictive index of IR in lean PCOS was a HOMA-M120 value of ≥12.8 or more (area under the ROC curve [AUC] 92.4%). In the ov-ob PCOS population, the best predictive performance was obtained by a Sib of ≤10.2 or less (AUC 85.7%).
CONCLUSION(S):
IR should be assessed in all PCOS women, both lean and ov-ob subjects. The HOMA-M120 resulted as a very simple tool, validated specifically for the lean PCOS woman whose cardiometabolic impairment is more frequently misunderstood.
Lingua originale | Inglese |
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pagine (da-a) | 250-256 |
Numero di pagine | 6 |
Rivista | Fertility and Sterility |
Volume | 102 |
DOI | |
Stato di pubblicazione | Pubblicato - 2014 |
Keywords
- insulinresistance
- polycystic ovary syndrome