Assessing upper limb function in nonambulant SMA patients: Development of a new module

Elena Stacy Mazzone; Flaviana Bianco; Daniela Martinelli; Allan M. Glanzman; Sonia Messina; Roberto De Sanctis; Marion Main; Michelle Eagle; Julaine Florence; Kristin Krosschell; Gessica Vasco; Marco Pelliccioni; Marilena Lombardo; Marika Pane; Richard Finkel; Francesco Muntoni; Enrico Bertini; Enrico Silvio Bertini; Eugenio Maria Mercuri

doi:10.1016/j.nmd.2011.02.014

Assessing upper limb function in nonambulant SMA patients: Development of a new module

Elena Stacy Mazzone, Flaviana Bianco, Daniela Martinelli, Allan M. Glanzman, Sonia Messina, Roberto De Sanctis, Marion Main, Michelle Eagle, Julaine Florence, Kristin Krosschell, Gessica Vasco, Marco Pelliccioni, Marilena Lombardo, Marika Pane, Richard Finkel, Francesco Muntoni, Enrico Bertini, Enrico Silvio Bertini, Eugenio Maria Mercuri

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

We report the development of a module specifically designed for assessing upper limb function in nonambulant SMA patients, including young children and those with severe contractures. The application of the module to a preschool cohort of 40 children (age 30-48 months) showed that all the items could be completed by 30 months.The module was also used in 45 nonambulant SMA patients (age 30 months to 27 years). Their scores were more variable than in the preschool cohort, ranging from 0 to 18. The magnitude of scores was not related to age (r= -0.19).The upper limb scores had a good correlation with the Hammersmith Functional Motor Scale, r= 0.75, but the upper limb function did not always strictly follow the overall gross motor function. These findings suggest that even some of the very weak nonambulant children possess upper limb skills that can be measured. © 2011 Elsevier B.V.

Lingua originale	English
pagine (da-a)	406-412
Numero di pagine	7
Rivista	Neuromuscular Disorders
Volume	21
DOI	https://doi.org/10.1016/j.nmd.2011.02.014
Stato di pubblicazione	Pubblicato - 2011

Keywords

Limb
Upper
Sma
Outcome measures

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10.1016/j.nmd.2011.02.014

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Mazzone, E. S., Bianco, F., Martinelli, D., Glanzman, A. M., Messina, S., Sanctis, R. D., Main, M., Eagle, M., Florence, J., Krosschell, K., Vasco, G., Pelliccioni, M., Lombardo, M., Pane, M., Finkel, R., Muntoni, F., Bertini, E., Bertini, E. S., & Mercuri, E. M. (2011). Assessing upper limb function in nonambulant SMA patients: Development of a new module. Neuromuscular Disorders, 21, 406-412. https://doi.org/10.1016/j.nmd.2011.02.014

@article{150d6b8d4f6442cca9d5886abb10d74d,

title = "Assessing upper limb function in nonambulant SMA patients: Development of a new module",

abstract = "We report the development of a module specifically designed for assessing upper limb function in nonambulant SMA patients, including young children and those with severe contractures. The application of the module to a preschool cohort of 40 children (age 30-48 months) showed that all the items could be completed by 30 months.The module was also used in 45 nonambulant SMA patients (age 30 months to 27 years). Their scores were more variable than in the preschool cohort, ranging from 0 to 18. The magnitude of scores was not related to age (r= -0.19).The upper limb scores had a good correlation with the Hammersmith Functional Motor Scale, r= 0.75, but the upper limb function did not always strictly follow the overall gross motor function. These findings suggest that even some of the very weak nonambulant children possess upper limb skills that can be measured. {\textcopyright} 2011 Elsevier B.V.",

keywords = "Limb, Upper, Sma, Outcome measures, Limb, Upper, Sma, Outcome measures",

author = "Mazzone, {Elena Stacy} and Flaviana Bianco and Daniela Martinelli and Glanzman, {Allan M.} and Sonia Messina and Sanctis, {Roberto De} and Marion Main and Michelle Eagle and Julaine Florence and Kristin Krosschell and Gessica Vasco and Marco Pelliccioni and Marilena Lombardo and Marika Pane and Richard Finkel and Francesco Muntoni and Enrico Bertini and Bertini, {Enrico Silvio} and Mercuri, {Eugenio Maria}",

year = "2011",

doi = "10.1016/j.nmd.2011.02.014",

language = "English",

volume = "21",

pages = "406--412",

journal = "Neuromuscular Disorders",

issn = "0960-8966",

publisher = "Elsevier Ltd",

}

Mazzone, ES, Bianco, F, Martinelli, D, Glanzman, AM, Messina, S, Sanctis, RD, Main, M, Eagle, M, Florence, J, Krosschell, K, Vasco, G, Pelliccioni, M, Lombardo, M, Pane, M, Finkel, R, Muntoni, F, Bertini, E, Bertini, ES & Mercuri, EM 2011, 'Assessing upper limb function in nonambulant SMA patients: Development of a new module', Neuromuscular Disorders, vol. 21, pagg. 406-412. https://doi.org/10.1016/j.nmd.2011.02.014

TY - JOUR

T1 - Assessing upper limb function in nonambulant SMA patients: Development of a new module

AU - Mazzone, Elena Stacy

AU - Bianco, Flaviana

AU - Martinelli, Daniela

AU - Glanzman, Allan M.

AU - Messina, Sonia

AU - Sanctis, Roberto De

AU - Main, Marion

AU - Eagle, Michelle

AU - Florence, Julaine

AU - Krosschell, Kristin

AU - Vasco, Gessica

AU - Pelliccioni, Marco

AU - Lombardo, Marilena

AU - Pane, Marika

AU - Finkel, Richard

AU - Muntoni, Francesco

AU - Bertini, Enrico

AU - Bertini, Enrico Silvio

AU - Mercuri, Eugenio Maria

PY - 2011

Y1 - 2011

N2 - We report the development of a module specifically designed for assessing upper limb function in nonambulant SMA patients, including young children and those with severe contractures. The application of the module to a preschool cohort of 40 children (age 30-48 months) showed that all the items could be completed by 30 months.The module was also used in 45 nonambulant SMA patients (age 30 months to 27 years). Their scores were more variable than in the preschool cohort, ranging from 0 to 18. The magnitude of scores was not related to age (r= -0.19).The upper limb scores had a good correlation with the Hammersmith Functional Motor Scale, r= 0.75, but the upper limb function did not always strictly follow the overall gross motor function. These findings suggest that even some of the very weak nonambulant children possess upper limb skills that can be measured. © 2011 Elsevier B.V.

AB - We report the development of a module specifically designed for assessing upper limb function in nonambulant SMA patients, including young children and those with severe contractures. The application of the module to a preschool cohort of 40 children (age 30-48 months) showed that all the items could be completed by 30 months.The module was also used in 45 nonambulant SMA patients (age 30 months to 27 years). Their scores were more variable than in the preschool cohort, ranging from 0 to 18. The magnitude of scores was not related to age (r= -0.19).The upper limb scores had a good correlation with the Hammersmith Functional Motor Scale, r= 0.75, but the upper limb function did not always strictly follow the overall gross motor function. These findings suggest that even some of the very weak nonambulant children possess upper limb skills that can be measured. © 2011 Elsevier B.V.

KW - Limb

KW - Upper

KW - Sma

KW - Outcome measures

KW - Limb

KW - Upper

KW - Sma

KW - Outcome measures

UR - http://hdl.handle.net/10807/260304

U2 - 10.1016/j.nmd.2011.02.014

DO - 10.1016/j.nmd.2011.02.014

M3 - Article

SN - 0960-8966

VL - 21

SP - 406

EP - 412

JO - Neuromuscular Disorders

JF - Neuromuscular Disorders

ER -

Assessing upper limb function in nonambulant SMA patients: Development of a new module

Abstract

Keywords

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