Appearance of new alpha-bungarotoxin-acetylcholine receptors in cultured sympathetic ganglia of chick embryos

Carlo Gangitano, Nicolo' Miani, L Fumagalli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

7 Citazioni (Scopus)

Abstract

alpha-Bungarotoxin (alpha-BuTX) has been used as a marker for studying the production of alpha-bungarotoxin-acetylcholine receptors (alpha-BuTX-AChRs) in explants of chick embryo sympathetic ganglia cultured in vitro. New alpha-BuTX-AChRs appear rapidly in the explants after blocking of the pre-existent ones with the toxin (40% of the total receptors at 3 h). There is a portion of alpha-BuTX-AChRs in the explants which for a short time is not accessible to the toxin. This portion constitutes the precursor pool of receptors and represents 18% of the total. The precursor pool of receptors supplies the neurons with new receptors for 1-2 h in the absence of protein synthesis. The appearance of new receptors from the precursor pool is an energy-dependent process.
Lingua originaleEnglish
pagine (da-a)131-141
Numero di pagine11
RivistaBrain Research
Volume161
Stato di pubblicazionePubblicato - 1979

Keywords

  • Acetylcholine
  • Animals
  • Autoradiography
  • Binding, Competitive
  • Bungarotoxins
  • Cell Differentiation
  • Chick Embryo
  • Ganglia, Autonomic
  • Models, Neurological
  • Receptors, Cholinergic
  • Tubocurarine

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