Apoptosis in normal and cancer stem cells

Ruggero De Maria Marchiano, Gioacchin Iannolo, Concetta Conticello, Lorenzo Memeo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

71 Citazioni (Scopus)

Abstract

Cancer stem cells, previously identified in acute leukemias, have now been isolated from several human malignancies, such as breast, brain and gastrointestinal tumors. The origin of these cells is still questionable, but a growing body of evidence supports the idea that they are responsible for tumor growth and maintenance. For this reason, they have become a primary subject of investigation with a view to developing novel therapies that might lead to the eradication of neoplastic diseases. As previously demonstrated, cancer stem cells in haematological diseases have biological properties similar to those of normal adult stem cells. Therefore, better knowledge of the apoptotic machinery in stem cells might help in the development of targeted therapy for treating cancers. In this review, we discuss some concepts relating to stem cell biology, focusing on the apoptotic responses of haematopoietic and neural stem cells to conventional and novel cancer treatment strategies. © 2007 Elsevier Ireland Ltd. All rights reserved.
Lingua originaleEnglish
pagine (da-a)42-51
Numero di pagine10
RivistaCRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume66
DOI
Stato di pubblicazionePubblicato - 2008

Keywords

  • AC133 Antigen
  • Animals
  • Antigens, CD
  • Antineoplastic Agents
  • Apoptosis
  • Cancer
  • Cancer stem cells
  • DNA Damage
  • Geriatrics and Gerontology
  • Glycoproteins
  • Hematology
  • Humans
  • Leukemia, Myeloid, Acute
  • Neoplastic Stem Cells
  • Oncology
  • Peptides
  • Stem Cells
  • Stem cells
  • bcl-X Protein

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