Abstract
The death ligand TRAIL was discovered just over 10 years ago. In this
chapter, we summarize the most important findings on the biochemistry,
biology and potential therapeutic applicability of this promising novel cytokine.
We address a number of eminent questions. How does TRAIL
apoptosis signaling work and what is special about it? Why is this member
of the tumor necrosis factor family of cytokines so interesting for cancer
researchers and immunologists? What is the physiological role of the
TRAIL–TRAIL receptor system? We cannot provide full answers to all of
these questions; however, we intend to point out to the reader the most
important unsolved scientific questions regarding the biology of this
fascinating cytokine and its receptors.
| Lingua originale | English |
|---|---|
| Titolo della pubblicazione ospite | Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts Volume 1, 26 May 2008 |
| Pagine | 31-92 |
| Numero di pagine | 62 |
| Volume | 1 |
| DOI | |
| Stato di pubblicazione | Pubblicato - 2008 |
Keywords
- Biochemistry
- Genetic aberrations
- Medicine (all)
- Physiological function
- Signaling
- Tumor tissue
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