Antiplatelet Drugs: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)

Carlo Patrono, C. Baigent, J. Hirsh, G. Roth

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

397 Citazioni (Scopus)

Abstract

This article about currently available antiplatelet drugs is part of the Antithrombotic and Thrombolytic Therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). It describes the mechanism of action, pharmacokinetics, and pharmacodynamics of aspirin, reversible cyclooxygenase inhibitors, thienopyridines, and integrin alphaIIbbeta3 receptor antagonists. The relationships among dose, efficacy, and safety are thoroughly discussed, with a mechanistic overview of randomized clinical trials. The article does not provide specific management recommendations; however, it does highlight important practical aspects related to antiplatelet therapy, including the optimal dose of aspirin, the variable balance of benefits and hazards in different clinical settings, and the issue of interindividual variability in response to antiplatelet drugs.
Lingua originaleEnglish
pagine (da-a)199-233
Numero di pagine35
RivistaChest
Volume133
Stato di pubblicazionePubblicato - 2008

Keywords

  • Antiplatelet drugs

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