Antioxidant saffron and central retinal function in ABCA4-related stargardt macular dystrophy

Marco Piccardi, Antonello Fadda, Francesco Martelli, Dario Marangoni, Adriano Magli, Angelo Maria Minnella, Matteo Bertelli, Stefano Di Marco, Silvia Bisti, Benedetto Falsini*

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

6 Citazioni (Scopus)


Retinal oxidative damage, associated with an ATP-binding cassette, sub-family A, member 4, also known as ABCA4 gene mutation, has been implicated as a major underlying mechanism for Stargardt disease/fundus flavimaculatus (STG/FF). Recent findings indicate that saffron carotenoid constituents crocins and crocetin may counteract retinal oxidative damage, inflammation and protect retinal cells from apoptosis. This pilot study aimed to evaluate central retinal function following saffron supplementation in STG/FF patients carrying ABCA4 mutations. Methods: in a randomized, double-blind, placebo-controlled study ( NCT01278277), 31 patients with ABCA4-related STG/FF and a visual acuity >0.25 were randomly assigned to assume oral saffron (20 mg) or placebo over a six month period and then reverted to P or S for a further six month period. Full ophthalmic examinations, as well as central 18◦ focal electroretinogram (fERG) recordings, were performed at baseline and after six months of either saffron or placebo. The fERG fundamental harmonic component was isolated by Fourier analysis. Main outcome measures were fERG amplitude (in µV) and phase (in degrees). The secondary outcome measure was visual acuity. Results: supplement was well tolerated by all patients throughout follow-up. After saffron, fERG amplitude was unchanged; after placebo, amplitude tended to decrease from baseline (mean change: −0.18 log µV, p < 0.05). Reverting the treatments, amplitude did not change significantly. fERG phase and visual acuity were unchanged throughout follow-up. Conclusions: short-term saffron supplementation was well tolerated and had no detrimental effects on the electroretinographic responses of the central retina and visual acuity. The current findings warrant further long-term clinical trials to assess the efficacy of saffron supplementation in slowing down the progression of central retinal dysfunction in ABCA4-related STG/FF.
Lingua originaleEnglish
pagine (da-a)2461-N/A
Stato di pubblicazionePubblicato - 2019


  • ABCA4 gene mutation
  • ATP-Binding Cassette Transporters
  • Administration, Oral
  • Adolescent
  • Adult
  • Aged
  • Antioxidants
  • Child
  • Crocus
  • Cross-Over Studies
  • Dietary Supplements
  • Double-Blind Method
  • Electroretinography
  • Female
  • Focal electroretinogram
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Middle Aged
  • Mutation
  • Neuroprotection
  • Oxidative Stress
  • Personalized medicine
  • Phenotype
  • Photoreceptors
  • Pilot Projects
  • Prospective Studies
  • Retina
  • Retinal function
  • Saffron
  • Stargardt Disease
  • Time Factors
  • Treatment Outcome
  • Visual Acuity
  • Young Adult


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