Antioxidant protection against acoustic trauma by coadministration of idebenone and vitamin E.

Bruno Sergi, Giuseppe Tringali, Roberto Piacentini, Anna Rita Fetoni, Aldo Ferraresi, Carmelo La Greca, Davide Rizzo, Diana Troiani

Risultato della ricerca: Contributo in rivistaArticolo in rivista

34 Citazioni (Scopus)

Abstract

Idebenone, a synthetic analogue of coenzyme Q, attenuates noise-induced hearing loss by virtue of its antioxidant properties. This study involves a guinea pig model of acoustic trauma where the effectiveness of idebenone is analyzed in comparison with Vitamin E (alpha-tocopherol) that exhibits a potent antioxidant activity in the inner ear. Idebenone and vitamin E were injected intraperitoneally 1 h before noise exposure and once daily for three days; functional and morphological studies were then carried out, respectively, by auditory brainstem responses evaluation, scanning electron microscopy and terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling assay identification of missing and apoptotic cells was also performed. The results showed that the protective effects of idebenone and vitamin E were not additive implying that the two antioxidants may share competitive mechanisms.
Lingua originaleEnglish
pagine (da-a)277-281
Numero di pagine5
RivistaNeuroReport
Stato di pubblicazionePubblicato - 2008

Keywords

  • Antioxidant
  • Idibenone
  • Neuroprotection

Fingerprint

Entra nei temi di ricerca di 'Antioxidant protection against acoustic trauma by coadministration of idebenone and vitamin E.'. Insieme formano una fingerprint unica.

Cita questo