Antioxidant and anti-inflammatory effects of selected natural compounds contained in a dietary supplement on two human immortalized keratinocyte lines

Simona Serini, Gabriella Calviello, Elena Fasano, Leonardo Celleno, Achille Renato Maria Cittadini, Nadia Mondella, Sonia Trombino

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

24 Citazioni (Scopus)

Abstract

Several advantages may derive from the use of dietary supplements containing multiple natural antioxidants and/or anti-inflammatory agents. At present, however, there is scarce information on the properties and potential of combined supplements. To fill the gap, the antioxidant and anti-inflammatory activities exerted by a combination of seven natural components (coenzyme Q10, krill oil, lipoic acid, resveratrol, grape seed oil, α-tocopherol, and selenium) contained in a dietary supplement used for the prevention of skin disorders were investigated in vitro. Each component was administered, alone or in combination, to human keratinocytes, and the inhibition of Reactive Oxygen Species production and lipid peroxidation as well as the ability to reduce inflammatory cytokine secretion and to modulate Nuclear Factor-κB pathway was evaluated. The combination exhibited high antioxidant activity and in specific conditions the combination's efficiency was higher than that of the most powerful components administered individually. Moreover, the combination showed remarkable anti-inflammatory properties. It reduced more efficiently than each component the secretion of Monocyte Chemoattractant Protein-1, a crucial cytokine for the development of chronic inflammation in skin, and inhibited Nuclear Factor-κB molecular pathway. Overall, our findings suggest that the combined formulation may have the potential to powerfully inhibit oxidative stress and inflammation at skin level.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
Numero di pagine11
RivistaBioMed Research International
Volume2014
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • Anti-Inflammatory Agents
  • Antioxidants
  • Biochemistry, Genetics and Molecular Biology (all)
  • Biological Products
  • Cell Line, Transformed
  • Chemokine CCL2
  • Dietary Supplements
  • Humans
  • Hydrogen Peroxide
  • I-kappa B Proteins
  • Immunology and Microbiology (all)
  • Inflammation
  • Interleukin-6
  • Keratin-13
  • Keratinocytes
  • Lipid Peroxidation
  • NF-KappaB Inhibitor alpha
  • Oxidative Stress
  • Phosphorylation
  • Plant Oils
  • alpha-Tocopherol

Fingerprint

Entra nei temi di ricerca di 'Antioxidant and anti-inflammatory effects of selected natural compounds contained in a dietary supplement on two human immortalized keratinocyte lines'. Insieme formano una fingerprint unica.

Cita questo