TY - JOUR
T1 - Antinuclear autoantibodies and pregnancy outcome in women with unexplained recurrent miscarriage
AU - Ticconi, Carlo
AU - Pietropolli, Adalgisa
AU - Borelli, Barbara
AU - Bruno, Valentina
AU - Piccione, Emilio
AU - Bernardini, Sergio
AU - Di Simone, Nicoletta
PY - 2016
Y1 - 2016
N2 - Problem: To investigate whether antinuclear autoantibodies (ANA) could be related to the outcome of the successive pregnancy in women with unexplained recurrent miscarriage (uRM). Methods: Circulating ANA were measured by indirect immunofluorescence in 86 women with uRM before pregnancy, repeated in the first trimester of the successive gestation and correlated with pregnancy outcome. Results: Forty-one women were ANA− and 45 were ANA+ before pregnancy. No relation was found between pre-pregnancy ANA status and the outcome of the successive pregnancy. However, when these women were monitored at 7th week during their pregnancy for ANA, of the 22 ANA+ women who remained ANA+ seven miscarriages (31.8%) were observed, whereas all of the 23 ANA+ women who became ANA− had pregnancies ongoing beyond the 20th week without miscarriage. Conclusions: ANA status could have a role in uRM. Disappearance of ANA in early pregnancy could have a favorable prognostic value in the successive pregnancy.
AB - Problem: To investigate whether antinuclear autoantibodies (ANA) could be related to the outcome of the successive pregnancy in women with unexplained recurrent miscarriage (uRM). Methods: Circulating ANA were measured by indirect immunofluorescence in 86 women with uRM before pregnancy, repeated in the first trimester of the successive gestation and correlated with pregnancy outcome. Results: Forty-one women were ANA− and 45 were ANA+ before pregnancy. No relation was found between pre-pregnancy ANA status and the outcome of the successive pregnancy. However, when these women were monitored at 7th week during their pregnancy for ANA, of the 22 ANA+ women who remained ANA+ seven miscarriages (31.8%) were observed, whereas all of the 23 ANA+ women who became ANA− had pregnancies ongoing beyond the 20th week without miscarriage. Conclusions: ANA status could have a role in uRM. Disappearance of ANA in early pregnancy could have a favorable prognostic value in the successive pregnancy.
KW - Immunology
KW - Immunology and Allergy
KW - Obstetrics and Gynecology
KW - Reproductive Medicine
KW - antinuclear autoantibodies
KW - autoimmunity
KW - recurrent miscarriage
KW - Immunology
KW - Immunology and Allergy
KW - Obstetrics and Gynecology
KW - Reproductive Medicine
KW - antinuclear autoantibodies
KW - autoimmunity
KW - recurrent miscarriage
UR - http://hdl.handle.net/10807/92059
U2 - 10.1111/aji.12560
DO - 10.1111/aji.12560
M3 - Article
SN - 1046-7408
SP - 396
EP - 399
JO - American Journal of Reproductive Immunology
JF - American Journal of Reproductive Immunology
ER -