TY - JOUR
T1 - Antimicrobial Resistance in Common Respiratory Pathogens of Chronic Bronchiectasis Patients: A Literature Review
AU - Inchingolo, Riccardo
AU - Pierandrei, Chiara
AU - Montemurro, Giuliano
AU - Smargiassi, Andrea
AU - Lohmeyer, Franziska Michaela
AU - Rizzi, Angela
PY - 2021
Y1 - 2021
N2 - Non-cystic fibrosis bronchiectasis is a chronic disorder in which immune system dysregulation
and impaired airway clearance cause mucus accumulation and consequent increased susceptibility to
lung infections. The presence of pathogens in the lower respiratory tract causes a vicious circle resulting
in impaired mucociliary function, bronchial inflammation, and progressive lung injury. In current
guidelines, antibiotic therapy has a key role in bronchiectasis management to treat acute exacerbations
and chronic infection and to eradicate bacterial colonization. Contrastingly, antimicrobial resistance,
with the risk of multidrug-resistant pathogen development, causes nowadays great concern. The aim of
this literature review was to assess the role of antibiotic therapy in bronchiectasis patient management
and possible concerns regarding antimicrobial resistance based on current evidence. The authors of this
review stress the need to expand research regarding bronchiectasis with the aim to assess measures to
reduce the rate of antimicrobial resistance worldwide.
AB - Non-cystic fibrosis bronchiectasis is a chronic disorder in which immune system dysregulation
and impaired airway clearance cause mucus accumulation and consequent increased susceptibility to
lung infections. The presence of pathogens in the lower respiratory tract causes a vicious circle resulting
in impaired mucociliary function, bronchial inflammation, and progressive lung injury. In current
guidelines, antibiotic therapy has a key role in bronchiectasis management to treat acute exacerbations
and chronic infection and to eradicate bacterial colonization. Contrastingly, antimicrobial resistance,
with the risk of multidrug-resistant pathogen development, causes nowadays great concern. The aim of
this literature review was to assess the role of antibiotic therapy in bronchiectasis patient management
and possible concerns regarding antimicrobial resistance based on current evidence. The authors of this
review stress the need to expand research regarding bronchiectasis with the aim to assess measures to
reduce the rate of antimicrobial resistance worldwide.
KW - non-cystic fibrosis bronchiectasis
KW - non-cystic fibrosis bronchiectasis
UR - http://hdl.handle.net/10807/203379
U2 - 10.3390/antibiotics10030326
DO - 10.3390/antibiotics10030326
M3 - Article
SN - 2079-6382
SP - 1
EP - 21
JO - Antibiotics
JF - Antibiotics
ER -