Antibodies anti-CagA cross-react with trophoblast cells: a risk factor for pre-eclampsia?

Francesco Franceschi, Nicoletta Di Simone, Giovanni Scambia, J. M. Campistol, A. Cases, J. López-Pedret, L. Revert

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

2 Citazioni (Scopus)

Abstract

Previous studies reported an epidemiological association between CagA-positive H. pylori strains and pre-eclampsia. As antibodies anti-CagA cross-react with endothelial cells and trophoblast cells show an endothelial phenotypic profile, we hypothesized that anti-CagA antibodies may recognize antigens of cytotrophoblast cells, thus impairing their function.
Lingua originaleEnglish
pagine (da-a)426-434
Numero di pagine9
RivistaHELICOBACTER
DOI
Stato di pubblicazionePubblicato - 2012

Keywords

  • Actins
  • Antibodies, Bacterial
  • Antigens, Bacterial
  • Bacterial Proteins
  • Cells, Cultured
  • Cross Reactions
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Fluorescent Antibody Technique
  • Humans
  • Pre-Eclampsia
  • Pregnancy
  • Risk Factors
  • Trophoblasts

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