Antibiotic therapy in small intestinal bacterial overgrowth: rifaximin versus metronidazole

Veronica Ojetti, Roberto Antonio Flore, Angelo Santoliquido, Paolo Tondi, Giovanni Battista Gasbarrini, Antonio Gasbarrini, Maurizio Gabrielli, Emidio Scarpellini, Davide Roccarina, Alessia Villita, Giovanni Ghirlanda, Ec Lauritano, E Fiore

Risultato della ricerca: Contributo in rivistaArticolo in rivista

66 Citazioni (Scopus)

Abstract

BACKGROUND AND OBJECTIVES: Few controlled trials on antibiotic therapy for small intestinal bacterial overgrowth are available at present. Aim of the study was to assess efficacy, safety and tolerability of rifaximin with respect to metronidazole for the treatment of small intestinal bacterial overgrowth. MATERIAL AND METHODS: We enrolled 142 consecutive patients with diagnosis of small intestinal bacterial overgrowth. Diagnosis of small intestinal bacterial overgrowth based on the clinical history and the positivity of glucose breath test. Patients were randomised to two 7-day treatment groups: rifaximin 1200 mg/day and metronidazole 750 mg/day. Glucose breath test was reassessed 1 month after. Compliance and side-effect incidence were also evaluated. RESULTS: One drop-out was observed in rifaximin group. Five drops-out occurred in metronidazole group. The glucose breath test normalization rate was significantly higher in the rifaximin with respect to the metronidazole group (63.4% versus 43.7%; p < 0.05; OR 1.50, 95% CI 1.14-4.38). The overall prevalence of adverse events was significantly lower in rifaximin with respect to metronidazole group. DISCUSSION: Rifaximin showed an higher SIBO decontamination rate than metronidazole at the tested doses, both with a significant gain in terms of tolerability. Either the present study or recent evidencies suggest that rifaximin represents a good choice for the management of patients affected by SIBO.
Lingua originaleEnglish
pagine (da-a)111-116
Numero di pagine6
RivistaEuropean Review for Medical and Pharmacological Sciences
Volume13
Stato di pubblicazionePubblicato - 2009

Keywords

  • Adult
  • Anti-Infective Agents
  • Bacterial Infections
  • Breath Tests
  • Female
  • Glucose
  • Humans
  • Intestine, Small
  • Male
  • Medication Adherence
  • Metronidazole
  • Middle Aged
  • Prospective Studies
  • Rifamycins
  • Young Adult

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