ANTIBIOBODIES - ANTIBIOTIC-LIKE ANTIIDIOTYPIC ANTIBODIES

Salvatore Conti, Massimo Castagnola, L Polonelli, M Gerloni, W Magliani, G Morace, C. Chezzi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Pathogenic micro-organisms such as Candida albicans may be susceptible to the activity of antimicrobial products like yeast killer toxins due to the presence of specific cell wall receptors for these agents. Anti-idiotypic antibodies (anti-Ids) were produced that competed for these receptors with the yeast killer toxin of a strain of Pichia anomala. We report here that affinity chromatography purified anti-Ids may kill C. albicans cells in vitro which are susceptible to the activity of the yeast killer toxin, as well as P. anomala killer cells which are obviously immune to their own toxin despite possessing specific cell wall receptors which can be detected by indirect immunofluorescence with anti-Ids. We propose that these conceptually new antimicrobial immunoglobulins acting as antibiotics be called `antibiobodies'.
Lingua originaleEnglish
pagine (da-a)235-242
Numero di pagine8
RivistaJournal of Medical and Veterinary Mycology
Volume29
Stato di pubblicazionePubblicato - 1991

Keywords

  • ANTIBIOTIC

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