Anti-tumor immunization of mothers delays tumor development in cancer prone offspring

Francesco Ria, Giuseppina Barutello, Claudia Curcio, Michela Spadaro, Maddalena Arigoni, Rosalinda Trovato, Elisabetta Bolli, Yujuan Zheng, Elena Quaglino, Manuela Iezzi, Federica Riccardo, Lars Holmgren, Guido Forni, Federica Cavallo

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

8 Citazioni (Scopus)

Abstract

Maternal immunization is successfully applied against some life-threatening infectious diseases as it can protect the mother and her offspring through the passive transfer of maternal antibodies. Here we sought to evaluate whether the concept of maternal immunization could also be applied to cancer immunoprevention. We have previously shown that antibodies induced by DNA vaccination against rat Her2 (neu) protect heterozygous neu-transgenic female (BALB-neuT) mice from autochthonous mammary tumor development. We herein seek to evaluate whether a similar, maternal, immunization can confer anti-tumor protection to BALB-neuT offspring. Significantly extended tumor-free survival was observed in BALB-neuT offspring born and fed by mothers vaccinated against neu, as compared to controls. Maternally derived anti-neu IgG were successfully transferred from mothers to newborns and were responsible for the protective effect. Vaccinated mother offspring also developed active immunity against neu as revealed by the presence of T-cell-mediated cytotoxicity against the neu immunodominant peptide. This active response was due to the milk transfer of immune-complexes that were formed between the neu extracellular domain, shed from vaccine-transfected muscle cells, and the anti-neu IgG induced by the vaccine. These findings show that maternal immunization has the potential to hamper mammary cancer in genetically predestinated offspring and to develop into applications against lethal neonatal cancer diseases for which therapeutic options are currently unavailable.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaOncoImmunology
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • anti-tumor vaccine
  • maternal immunization

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