Anti-tissue transglutaminase antibodies from celiac patients are responsible for trophoblast damage via apoptosis in vitro

Nicoletta Di Simone; M Silano; Roberta Castellani; Fiorella Di Nicuolo; Mc D'Alessio; Francesco Franceschi; Alessandra Tritarelli; Antonio Maria Leone; Chiara Tersigni; Giovanni Battista Gasbarrini; Ng Silveri; Alessandro Caruso; Antonio Gasbarrini

doi:10.1038/ajg.2010.233

Anti-tissue transglutaminase antibodies from celiac patients are responsible for trophoblast damage via apoptosis in vitro

Nicoletta Di Simone
, M Silano
, Roberta Castellani
, Fiorella Di Nicuolo
, Mc D'Alessio
, Francesco Franceschi
, Alessandra Tritarelli
, Antonio Maria Leone
, Chiara Tersigni
, Giovanni Battista Gasbarrini
, Ng Silveri
, Alessandro Caruso
, Antonio Gasbarrini^*

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo

47 Citazioni (Scopus)

Abstract

The association between maternal celiac disease (CD) and both reduced fertility and increased risk of adverse pregnancy-related events has been long documented. However, no evidences are available regarding the pathogenic mechanisms of this link. The aim of this study was to determine whether anti-tissue transglutaminase (anti-tTG) antibodies are involved in the damage of trophoblastic cells in vitro.

Lingua originale	Inglese
pagine (da-a)	2254-2261
Numero di pagine	8
Rivista	THE AMERICAN JOURNAL OF GASTROENTEROLOGY
Volume	105
Numero di pubblicazione	10
DOI	https://doi.org/10.1038/ajg.2010.233
Stato di pubblicazione	Pubblicato - 2010

All Science Journal Classification (ASJC) codes

Epatologia
Gastroenterologia

Keywords

Anti-Idiotypic
Antibodies
Apoptosis
Celiac Disease
Cells
Cultured
Female
Flow Cytometry
Humans
In Situ Nick-End Labeling
Placenta
Pregnancy
Transglutaminases
Trophoblasts

Accesso al documento

10.1038/ajg.2010.233

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Di Simone, N., Silano, M., Castellani, R., Di Nicuolo, F., D'Alessio, M., Franceschi, F., Tritarelli, A., Leone, A. M., Tersigni, C., Gasbarrini, G. B., Silveri, N., Caruso, A., & Gasbarrini, A. (2010). Anti-tissue transglutaminase antibodies from celiac patients are responsible for trophoblast damage via apoptosis in vitro. THE AMERICAN JOURNAL OF GASTROENTEROLOGY, 105(10), 2254-2261. https://doi.org/10.1038/ajg.2010.233

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title = "Anti-tissue transglutaminase antibodies from celiac patients are responsible for trophoblast damage via apoptosis in vitro",

abstract = "The association between maternal celiac disease (CD) and both reduced fertility and increased risk of adverse pregnancy-related events has been long documented. However, no evidences are available regarding the pathogenic mechanisms of this link. The aim of this study was to determine whether anti-tissue transglutaminase (anti-tTG) antibodies are involved in the damage of trophoblastic cells in vitro.",

keywords = "Anti-Idiotypic, Antibodies, Apoptosis, Celiac Disease, Cells, Cultured, Female, Flow Cytometry, Humans, In Situ Nick-End Labeling, Placenta, Pregnancy, Transglutaminases, Trophoblasts, Anti-Idiotypic, Antibodies, Apoptosis, Celiac Disease, Cells, Cultured, Female, Flow Cytometry, Humans, In Situ Nick-End Labeling, Placenta, Pregnancy, Transglutaminases, Trophoblasts",

author = "\{Di Simone\}, Nicoletta and M Silano and Roberta Castellani and \{Di Nicuolo\}, Fiorella and Mc D'Alessio and Francesco Franceschi and Alessandra Tritarelli and Leone, \{Antonio Maria\} and Chiara Tersigni and Gasbarrini, \{Giovanni Battista\} and Ng Silveri and Alessandro Caruso and Antonio Gasbarrini",

year = "2010",

doi = "10.1038/ajg.2010.233",

language = "English",

volume = "105",

pages = "2254--2261",

journal = "THE AMERICAN JOURNAL OF GASTROENTEROLOGY",

issn = "0002-9270",

publisher = "New York, NY: Elsevier Science Incorporated -New York: National Gastroenterological Association",

number = "10",

}

Di Simone, N, Silano, M, Castellani, R, Di Nicuolo, F, D'Alessio, M, Franceschi, F, Tritarelli, A, Leone, AM, Tersigni, C, Gasbarrini, GB, Silveri, N, Caruso, A & Gasbarrini, A 2010, 'Anti-tissue transglutaminase antibodies from celiac patients are responsible for trophoblast damage via apoptosis in vitro', THE AMERICAN JOURNAL OF GASTROENTEROLOGY, vol. 105, n. 10, pagg. 2254-2261. https://doi.org/10.1038/ajg.2010.233

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AU - Di Simone, Nicoletta

AU - Silano, M

AU - Castellani, Roberta

AU - Di Nicuolo, Fiorella

AU - D'Alessio, Mc

AU - Franceschi, Francesco

AU - Tritarelli, Alessandra

AU - Leone, Antonio Maria

AU - Tersigni, Chiara

AU - Gasbarrini, Giovanni Battista

AU - Silveri, Ng

AU - Caruso, Alessandro

AU - Gasbarrini, Antonio

PY - 2010

Y1 - 2010

N2 - The association between maternal celiac disease (CD) and both reduced fertility and increased risk of adverse pregnancy-related events has been long documented. However, no evidences are available regarding the pathogenic mechanisms of this link. The aim of this study was to determine whether anti-tissue transglutaminase (anti-tTG) antibodies are involved in the damage of trophoblastic cells in vitro.

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KW - Apoptosis

KW - Celiac Disease

KW - Cells

KW - Cultured

KW - Female

KW - Flow Cytometry

KW - Humans

KW - In Situ Nick-End Labeling

KW - Placenta

KW - Pregnancy

KW - Transglutaminases

KW - Trophoblasts

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KW - Antibodies

KW - Apoptosis

KW - Celiac Disease

KW - Cells

KW - Cultured

KW - Female

KW - Flow Cytometry

KW - Humans

KW - In Situ Nick-End Labeling

KW - Placenta

KW - Pregnancy

KW - Transglutaminases

KW - Trophoblasts

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ER -

Anti-tissue transglutaminase antibodies from celiac patients are responsible for trophoblast damage via apoptosis in vitro

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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