Anti-tissue transglutaminase antibodies from celiac patients are responsible for trophoblast damage via apoptosis in vitro

Francesco Franceschi, Giovanni Battista Gasbarrini, Antonio Gasbarrini, Nicoletta Di Simone, Antonio Maria Leone, Chiara Tersigni, Marco Silano

Risultato della ricerca: Contributo in rivistaArticolo in rivista

47 Citazioni (Scopus)

Abstract

The association between maternal celiac disease (CD) and both reduced fertility and increased risk of adverse pregnancy-related events has been long documented. However, no evidences are available regarding the pathogenic mechanisms of this link. The aim of this study was to determine whether anti-tissue transglutaminase (anti-tTG) antibodies are involved in the damage of trophoblastic cells in vitro.
Lingua originaleEnglish
pagine (da-a)2254-2261
Numero di pagine8
RivistaAmerican Journal of Gastroenterology
Volume105
DOI
Stato di pubblicazionePubblicato - 2010

Keywords

  • Antibodies, Anti-Idiotypic
  • Apoptosis
  • Celiac Disease
  • Cells, Cultured
  • Female
  • Flow Cytometry
  • Humans
  • In Situ Nick-End Labeling
  • Placenta
  • Pregnancy
  • Transglutaminases
  • Trophoblasts

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