Abstract
Objective To evaluate anti-Müllerian hormone (AMH) concentrations and antral follicle counts (AFCs) in the prediction of pregnancy outcomes after controlled ovarian stimulation among women undergoing intrauterine insemination. Methods A retrospective study included women with unexplained infertility aged 41 years or younger who attended a fertility clinic in Italy between December 2009 and May 2014. Ovarian stimulation was achieved with recombinant follicle-stimulating hormone or highly purified human menopausal gonadotropin. Receiver operating characteristic curves were generated to predict ongoing pregnancy. The primary outcome was the association between AMH/AFC and ongoing pregnancy, and was assessed by logistic regression. Results Overall, 276 women were included, of whom 43 (15.6%) achieved ongoing pregnancy. Multivariate analysis showed that women with a serum day-3 concentration of AMH higher than 2.3 ng/mL were more likely to have ongoing pregnancy than were those with a concentration lower than 2.3 ng/mL (odds ratio 5.84, 95% confidence interval 2.38-14.31; P < 0.001). No associations were recorded for AFCs. Conclusion AMH should be used to predict the pregnancy outcome of intrauterine insemination.
Lingua originale | English |
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pagine (da-a) | 64-68 |
Numero di pagine | 5 |
Rivista | INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS |
Volume | 133 |
DOI | |
Stato di pubblicazione | Pubblicato - 2016 |
Keywords
- Adult
- Anti-Mullerian Hormone
- Anti-Müllerian hormone
- Antral follicle count
- Female
- Follicle Stimulating Hormone
- Humans
- Infertility, Female
- Insemination, Artificial
- Intrauterine insemination
- Italy
- Logistic Models
- Menotropins
- Multivariate Analysis
- Obstetrics and Gynecology
- Ovarian Follicle
- Ovulation Induction
- Ovulation induction
- Prediction
- Pregnancy
- Pregnancy Outcome
- Retrospective Studies