Anti-acetylcholinesterase antibodies associate with ocular myasthenia gravis.

Carlo Provenzano, Mariapaola Marino, Amelia Evoli, Flavia Scuderi, Emanuela Bartoccioni

Risultato della ricerca: Contributo in rivistaArticolo in rivista

14 Citazioni (Scopus)

Abstract

In MG, anti-AChR or anti-MuSK abs impair neuromuscular transmission. Partial inhibition of AChE can ameliorate symptoms, while a complete block causes a cholinergic blockade. We found anti-AChE abs in 115/240 MG patients, with no correlation with sex, age at onset, thymus pathology, presence of anti-AChR or anti-MuSK antibodies. We found a correlation with the ocular form of the disease, and with milder forms of MG not requiring immunosuppressants; moreover, when we considered only those patients who were off AChEI therapy, we found that ocular patients were positive for anti-AChE abs, while generalized patients were negative. According to an experimental model, we hypothesize that anti-AChE abs could contribute to ptosis through an inhibition of the sympathetic innervation of the tarsal muscle.
Lingua originaleEnglish
pagine (da-a)102-106
Numero di pagine5
RivistaJournal of Neuroimmunology
Volume2010
DOI
Stato di pubblicazionePubblicato - 2010

Keywords

  • acetylcholinesterase
  • myasthenia gravis
  • ocular myasthenia

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