Antenatal Glucocorticoids Supplementation and Central Nervous System Development

Fabrizio Michetti, Diego Gazzolo, Laura D. Serpero, Alessandro Frigiola, Raul Abella, Alessandro Giamberti, Giovanni Li Volti

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

3 Citazioni (Scopus)

Abstract

Maternal antenatal therapy with glucocorticoids (GC) is routinely used to prevent lung immaturity. The potential harmful effects on other organs, including in particular the central nervous system (CNS), are still controversial. In the present review we aimed to investigate: i) the beneficial and detrimental effects of antenatal GC treatment in both human and animal models; ii) the potential usefulness of biochemical markers such as calcium binding proteins (S100B, synaptophysin) and cytoskeletal protein of neurons and dendrites (MAP2) in the perinatal period, and iii) whether the assessment of brain markers in different biological fluids could constitute a promising tool for the monitoring of CNS function and/or developmental in fetuses and newborns whose mothers assumed GC antenatally.
Lingua originaleEnglish
pagine (da-a)160-166
Numero di pagine7
RivistaCURRENT DRUG METABOLISM
Volume2013
Stato di pubblicazionePubblicato - 2013
Pubblicato esternamente

Keywords

  • glucocorticoids

Fingerprint

Entra nei temi di ricerca di 'Antenatal Glucocorticoids Supplementation and Central Nervous System Development'. Insieme formano una fingerprint unica.

Cita questo