Anodal transcranial direct current stimulation boosts synaptic plasticity and memory in mice via epigenetic regulation of Bdnf expression

Maria Vittoria Podda, Salvatore Fusco, Lucia Leone, Cristian Ripoli, Claudio Grassi, Sara Cocco, Alessia Mastrodonato, Saviana Antonella Barbati, Claudia Colussi

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

89 Citazioni (Scopus)

Abstract

The effects of transcranial direct current stimulation (tDCS) on brain functions and the underlying molecular mechanisms are yet largely unknown. Here we report that mice subjected to 20-min anodal tDCS exhibited one-week lasting increases in hippocampal LTP, learning and memory. These effects were associated with enhanced: i) acetylation of brain-derived neurotrophic factor (Bdnf) promoter I; ii) expression of Bdnf exons I and IX; iii) Bdnf protein levels. The hippocampi of stimulated mice also exhibited enhanced CREB phosphorylation, pCREB binding to Bdnf promoter I and recruitment of CBP on the same regulatory sequence. Inhibition of acetylation and blockade of TrkB receptors hindered tDCS effects at molecular, electrophysiological and behavioral levels. Collectively, our findings suggest that anodal tDCS increases hippocampal LTP and memory via chromatin remodeling of Bdnf regulatory sequences leading to increased expression of this gene, and support the therapeutic potential of tDCS for brain diseases associated with impaired neuroplasticity.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
Numero di pagine19
RivistaScientific Reports
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • Bdnf
  • Hippocampus
  • epigenetics
  • memory
  • synaptic plasticity
  • transcranial direct current stimulation

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