Angiogenic impairment of the vascular endothelium: a novel mechanism and potential therapeutic target in muscular dystrophy

Eleonora Gaetani, Roberto Pola, Mariangela Palladino, Ilaria Gatto, Valentina Neri, Margherita Marcantoni, Igor Giarretta, Egidio Stigliano, Raffaele Landolfi, Stefania Straino, Roy C. Smith, Marcy Silver, Maurizio Capogrossi, Lynn Hlatky

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

35 Citazioni (Scopus)

Abstract

Dystrophin, the missing or defective protein in Duchenne muscular dystrophy, is expressed not only in muscle cells but also in vascular endothelial cells (ECs). In this study, we assessed the effects of dystrophin deficiency on the angiogenic capacities of ECs.
Lingua originaleEnglish
pagine (da-a)2867-2876
Numero di pagine10
RivistaArteriosclerosis, Thrombosis, and Vascular Biology
Volume33
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • Animals
  • Apoptosis
  • Aspirin
  • Carcinoma, Lewis Lung
  • Caveolin 1
  • Cell Aging
  • Cell Movement
  • Cell Proliferation
  • Cells, Cultured
  • Coculture Techniques
  • Corneal Neovascularization
  • Cyclic GMP
  • Disease Models, Animal
  • Dystrophin
  • Endothelial Cells
  • Endothelium, Vascular
  • Ischemia
  • Mice
  • Mice, Inbred mdx
  • Muscular Dystrophy, Duchenne
  • Mutation
  • Myoblasts, Skeletal
  • Neovascularization, Pathologic
  • Neovascularization, Physiologic
  • Nitric Oxide
  • Nitric Oxide Synthase Type III
  • Time Factors
  • angiogenesis inhibitors
  • endothelium, vascular
  • muscle diseases, inflammatory
  • nitric oxide synthase type III

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