TY - JOUR
T1 - Angina after percutaneous coronary intervention: The need for precision medicine
AU - Niccoli, Giampaolo
AU - Montone, Rocco Antonio
AU - Lanza, Gaetano Antonio
AU - Crea, Filippo
PY - 2017
Y1 - 2017
N2 - Persistence or recurrence of angina after successful percutaneous coronary intervention (PCI) represent an important clinical issue involving from one fifth to one third of patients undergoing myocardial revascularization at one-year follow-up. A systematic approach to this syndrome is strongly needed. Precision medicine is particularly important in addressing angina after successful PCI because of the multiple underlying causes. Restenosis or coronary atherosclerosis progression explain symptom recurrence after successful PCI in some patients, while functional causes, including vasomotor abnormalities of epicardial coronary arteries and/or coronary microvascular dysfunction, explain symptoms in the remaining patients. In this review, we summarize the mechanisms of persistent or recurrent angina after PCI, proposing a diagnostic algorithm and a systematic therapeutic approach.
AB - Persistence or recurrence of angina after successful percutaneous coronary intervention (PCI) represent an important clinical issue involving from one fifth to one third of patients undergoing myocardial revascularization at one-year follow-up. A systematic approach to this syndrome is strongly needed. Precision medicine is particularly important in addressing angina after successful PCI because of the multiple underlying causes. Restenosis or coronary atherosclerosis progression explain symptom recurrence after successful PCI in some patients, while functional causes, including vasomotor abnormalities of epicardial coronary arteries and/or coronary microvascular dysfunction, explain symptoms in the remaining patients. In this review, we summarize the mechanisms of persistent or recurrent angina after PCI, proposing a diagnostic algorithm and a systematic therapeutic approach.
KW - Angina
KW - Cardiology and Cardiovascular Medicine
KW - Microvascular dysfunction
KW - Percutaneous coronary intervention
KW - Angina
KW - Cardiology and Cardiovascular Medicine
KW - Microvascular dysfunction
KW - Percutaneous coronary intervention
UR - http://hdl.handle.net/10807/119187
UR - http://www.elsevier.com/locate/ijcard
U2 - 10.1016/j.ijcard.2017.07.105
DO - 10.1016/j.ijcard.2017.07.105
M3 - Article
SN - 0167-5273
SP - 14
EP - 19
JO - International Journal of Cardiology
JF - International Journal of Cardiology
ER -