TY - JOUR
T1 - Analytical methods for peptide drugs applicable to process control
AU - Castagnola, Massimo
AU - FACOLTA', DI MEDICINA E CHIRURGIA "A.GEMELLI"
AU - FACOLTA', DI MEDICINA E CHIRURGIA "A.GEMELLI"
AU - Rossetti, D
AU - FACOLTA', DI MEDICINA E CHIRURGIA "A.GEMELLI"
AU - Misiti, F
AU - Cassiano, L
AU - FACOLTA', DI MEDICINA E CHIRURGIA "A.GEMELLI"
AU - Giardina, B
AU - Messana, I.
PY - 1997
Y1 - 1997
N2 - This review describes new analytical methodologies applicable to peptide
purity validation and process control, The HPLC section is centered on
the description of new stationary phases, which could offer better
performance with respect to the well consolidated RP-HPLC techniques. In
the chapter devoted to capillary electrophoresis the different options
offered by zonal procedures are particularly stressed. The applications
of either capillary electrophoresis in polymeric solutions, either
isoelectric focusing as well as of isotacophoresis are subsequently
discussed. The section devoted to the description of electrochromatography emphasizes, in particular, micellar electrokinetic capillary chromatography. Furthermore, future applications of packed
electrochromatography are illustrated. The conclusion is dedicated to
several hyphenated opportunities and future perspectives of peptide
analysis, as micro total analytical systems. (C) 1997 Elsevier Science
B.V.
AB - This review describes new analytical methodologies applicable to peptide
purity validation and process control, The HPLC section is centered on
the description of new stationary phases, which could offer better
performance with respect to the well consolidated RP-HPLC techniques. In
the chapter devoted to capillary electrophoresis the different options
offered by zonal procedures are particularly stressed. The applications
of either capillary electrophoresis in polymeric solutions, either
isoelectric focusing as well as of isotacophoresis are subsequently
discussed. The section devoted to the description of electrochromatography emphasizes, in particular, micellar electrokinetic capillary chromatography. Furthermore, future applications of packed
electrochromatography are illustrated. The conclusion is dedicated to
several hyphenated opportunities and future perspectives of peptide
analysis, as micro total analytical systems. (C) 1997 Elsevier Science
B.V.
KW - PEPTIDE
KW - PEPTIDE
UR - http://hdl.handle.net/10807/25456
M3 - Article
VL - 10
SP - 181
EP - 203
JO - Process Control and Quality
JF - Process Control and Quality
SN - 0924-3089
ER -