An updated safety review of the drug treatments for idiopathic pulmonary fibrosis

Alessia Comes, Luca Richeldi, Giacomo Sgalla

Risultato della ricerca: Contributo in rivistaEditoriale in rivista / quotidiano

Abstract

Introduction The approval of antifibrotic agents nintedanib and pirfenidone revolutionized the management of idiopathic pulmonary fibrosis (IPF). These treatments showed acceptable tolerability in randomized-clinical trials; however, they have been associated with a spectrum of potential side effects which require careful assessment of risks and benefits in the individual patient before commencing and during antifibrotic therapy. Areas covered The accrued evidence on safety of nintedanib and pirfenidone is summarized, from the first randomized clinical trials to the open-label extension studies and post-marketing clinical experiences which helped clarify the long-term tolerability of these drugs. Expert opinion The data collected over the last years confirmed the comparable tolerability profile of nintedanib and pirfenidone. The physician's assessment of expected side effects may help decide the optimal first-line therapy for the individual patient. Patient's counseling during treatment remains essential to manage emerging adverse events and eventually inform the decision of drug discontinuation.
Lingua originaleEnglish
pagine (da-a)1035-1048-1048
RivistaExpert Opinion on Drug Safety
Volume20
DOI
Stato di pubblicazionePubblicato - 2021

Keywords

  • Anti-Inflammatory Agents, Non-Steroidal
  • Humans
  • Idiopathic Pulmonary Fibrosis
  • Idiopathic pulmonary fibrosis
  • Indoles
  • Patient Education as Topic
  • Protein Kinase Inhibitors
  • Pyridones
  • Randomized Controlled Trials as Topic
  • nintedanib
  • pirfenidone
  • safety
  • tolerability

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