An update on pancreatic regeneration mechanisms: Searching for paths to a cure for type 2 diabetes

Laura Soldovieri, Gianfranco Di Giuseppe, Gea Ciccarelli, Giuseppe Quero, Francesca Cinti, Michela Brunetti, Enrico Celestino Nista, Antonio Gasbarrini, Sergio Alfieri, Alfredo Pontecorvi, Andrea Giaccari, Teresa Mezza

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Background: Over the last decades, various approaches have been explored to restore sufficient (3-cell mass in diabetic patients. Stem cells are certainly an attractive source of new (3-cells, but an alternative option is to induce the endogenous regeneration of these cells.Scope of Review: Since the exocrine and endocrine pancreatic glands have a common origin and a continuous crosstalk unites the two, we believe that analyzing the mechanisms that induce pancreatic regeneration in different conditions could further advance our knowledge in the field. In this review, we summarize the latest evidence on physiological and pathological conditions associated with the regulation of pancreas regeneration and proliferation, as well as the complex and coordinated signaling cascade mediating cell growth.Major conclusions: Unraveling the mechanisms involved in intracellular signaling and regulation of pancreatic cell proliferation and regeneration may inspire future investigations to discover potential strategies to cure diabetes. & COPY; 2023 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Lingua originaleEnglish
pagine (da-a)1-19
Numero di pagine19
RivistaMolecular Metabolism
Volume74
DOI
Stato di pubblicazionePubblicato - 2023

Keywords

  • Exocrine pancreas
  • Islet plasticity
  • Pancreas regeneration
  • Proliferation

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