@article{d2630ae2bc594f5fa021376695dd96e0,
title = "An inflammatory profile correlates with decreased frequency of cytotoxic cells in coronavirus disease 2019",
abstract = "Increased production of inflammatory cytokines and myeloid-derived suppressor cells occurs in patients with coronavirus disease 2019. These inversely correlated with perforin-expressing natural killer (NK) and CD3+ T cells. We observed a lower number of perforin-expressing NK cells in intensive care unit (ICU) patients compared with non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism.",
keywords = "COVID-19, cytotoxic cells, NK cells, MDSC, inflammation, COVID-19, cytotoxic cells, NK cells, MDSC, inflammation",
author = "Veronica Bordoni and Alessandra Sacchi and Eleonora Cimini and Stefania Notari and Germana Grassi and Eleonora Tartaglia and Rita Casetti and Giancola, \{Maria Letizia\} and Nazario Bevilacqua and Markus Maeurer and Alimuddin Zumla and Franco Locatelli and \{De Benedetti\}, Fabrizio and Fabrizio Palmieri and Luisa Marchioni and Capobianchi, \{Maria R\} and Gianpiero D'Offizi and Nicola Petrosillo and Andrea Antinori and Emanuele Nicastri and Giuseppe Ippolito and Chiara Agrati",
year = "2020",
doi = "10.1093/cid/ciaa577",
language = "English",
volume = "71",
pages = "2272--2275",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
}