TY - JOUR
T1 - An Emerging Role of Endometrial Inflammosome in Reproduction: New Therapeutic Approaches
AU - Pontecorvi, Alfredo
AU - Scambia, Giovanni
AU - Di Simone, Nicoletta
PY - 2018
Y1 - 2018
N2 - One of the common complications of pregnancy is spontaneous pregnancy
loss which occurs in an estimated 5- 15% of pregnancies. Of all women 1%–5% suffer from recurrent
pregnancy loss (RPL). Despite the fact that RPL has been associated to various anatomic, hormonal,
immune, hematologic, and genetic defects, in 30% of the patients, screening tests included
in the RPL workup may have negative results. Recently, we demonstrated a significant increased
activation of endometrial NALP-3 inflammasome, and a caspase-1 dependent secretion of IL-18
and IL-1β in the endometrial tissues obtained from RPL women compared with a fertile women
group. The inflammasome has emerged as a key player in innate immunity and inflammation. An
abnormal inflammasome activation, in absence of detectable infectious causes, might be one of the
molecular mechanisms involved in establishing an unreceptive endometrium, potentially leading to
early fetal loss. Upon activation, this multiprotein complex makes possible the caspase-1-mediated
proteolytic processing of proinflammatory cytokines generating their respective mature secretory
forms.
Conclusion: The understanding of molecular modulation of inflammasome associated pathways is
AB - One of the common complications of pregnancy is spontaneous pregnancy
loss which occurs in an estimated 5- 15% of pregnancies. Of all women 1%–5% suffer from recurrent
pregnancy loss (RPL). Despite the fact that RPL has been associated to various anatomic, hormonal,
immune, hematologic, and genetic defects, in 30% of the patients, screening tests included
in the RPL workup may have negative results. Recently, we demonstrated a significant increased
activation of endometrial NALP-3 inflammasome, and a caspase-1 dependent secretion of IL-18
and IL-1β in the endometrial tissues obtained from RPL women compared with a fertile women
group. The inflammasome has emerged as a key player in innate immunity and inflammation. An
abnormal inflammasome activation, in absence of detectable infectious causes, might be one of the
molecular mechanisms involved in establishing an unreceptive endometrium, potentially leading to
early fetal loss. Upon activation, this multiprotein complex makes possible the caspase-1-mediated
proteolytic processing of proinflammatory cytokines generating their respective mature secretory
forms.
Conclusion: The understanding of molecular modulation of inflammasome associated pathways is
KW - endometrium
KW - miscarriage
KW - endometrium
KW - miscarriage
UR - http://hdl.handle.net/10807/128737
U2 - 10.2174/0929866525666180412160045
DO - 10.2174/0929866525666180412160045
M3 - Article
SN - 1875-5305
SP - 455
EP - 462
JO - PROTEIN & PEPTIDE LETTERS
JF - PROTEIN & PEPTIDE LETTERS
ER -