An aza-macrocycle containing maltolic side-arms (maltonis) as potential drug against human pediatric sarcomas

Mario Balducci, Clara Guerzoni, Stefano Amatori, Luca Giorgi, Maria C. Manara, Lorena Landuzzi, Pier-Luigi Lollini, Aurora Tassoni, Mauro Balducci, Marco Manfrini, Loredana Pratelli, Massimo Serra, Piero Picci, Mauro Magnani, Vieri Fusi, Mirco Fanelli, Katia Scotlandi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

11 Citazioni (Scopus)

Abstract

Identification of new drugs against paediatric sarcomas represents an urgent clinical need that mainly relies on public investments due to the rarity of these diseases. In this paper we evaluated the in vitro and in vivo efficacy of a new maltol derived molecule (maltonis), belonging to the family of molecules named hydroxypyrones.
Lingua originaleEnglish
pagine (da-a)137-137
Numero di pagine1
RivistaBMC Cancer
Volume14
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • Animals
  • Antineoplastic Agents
  • Apoptosis
  • Cell Cycle
  • Cell Line, Tumor
  • Cell Proliferation
  • Child
  • DNA Damage
  • Disease Models, Animal
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic
  • Heterocyclic Compounds
  • Heterografts
  • Humans
  • Inhibitory Concentration 50
  • Mesenchymal Stromal Cells
  • Mice
  • Sarcoma

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