Amniotic fluid levels of S100B protein in normal and Trysomy-21 foetuses

Diego Gazzolo, Matteo Bruschettini, Valentina Corvino, Mario Lituania, Rossana Sarli, Pierluigi Bruschettini, Fabrizio Michetti

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review


BACKGROUND: The human chromosome 21 has been shown to contain the gene for the beta subunit of the S100B protein. The present case-control study was aimed at investigating whether overproduction of S100B protein is detectable in the amniotic fluid of foetuses with trisomy-21. METHODS: Measurements of S100B in amniotic fluid samples from 14 pregnant women with trisomy-21 foetuses were compared with those obtained from 182 physiological pregnancies. S100B was measured in the samples using an immunoluminometric assay (LIA-mat Sangtec 100). RESULTS: Our results showed that S100B protein amniotic fluid levels were significantly higher in trisomy-21 foetuses (0.83+/-0.21 microg/l) than in controls (0.51+/-0.22 microg/l) (p<0.05). CONCLUSION: The present finding supports the notion that the expression of S100B is increased in trisomy-21 foetuses; it also constitutes a prerequisite basis for a possible involvement of the protein in pathogenic processes associated with trisomy-21, and/or for its potential employment as a diagnostic tool.
Lingua originaleEnglish
pagine (da-a)131-133
Numero di pagine3
RivistaClinica Chimica Acta;
Stato di pubblicazionePubblicato - 2003


  • Foetus
  • S100B protein


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