Amnion: a potent graft source for cell therapy in stroke

Ornella Parolini, Jin Yu Seong, Maddalena Soncini, Yuji Kaneko, David C. Hess, Cesar V. Borlongan

Risultato della ricerca: Contributo in rivistaArticolo in rivista

70 Citazioni (Scopus)

Abstract

[Ita:]Regenerative medicine is a new field primarily based on the concept of transplanting exogenous or stimulating endogenous stem cells to generate biological substitutes and improve tissue functions. Recently, amnion-derived cells have been reported to have multipotent differentiation ability, and these cells have attracted attention as a novel cell source for cell transplantation therapy. Cells isolated from amniotic membrane can differentiate into all three germ layers, have low immunogenicity and anti-inflammatory function, and do not require the destruction of human embryos for their isolation, thus circumventing the ethical debate commonly associated with the use of human embryonic stem cells. Accumulating evidence now suggests that the amnion, which had been discarded after parturition, is a highly potent transplant material in the field of regenerative medicine. In this report, we review the current progress on the characterization of MSCs derived from the amnion as a remarkable transplantable cell population with therapeutic potential for multiple CNS disorders, especially stroke.
Lingua originaleEnglish
pagine (da-a)111-118
Numero di pagine8
RivistaCell Transplantation
Volume18
DOI
Stato di pubblicazionePubblicato - 2009

Keywords

  • Adult Stem Cells
  • Amnion
  • Cells, Cultured
  • Embryonic Stem Cells
  • Humans
  • Mesenchymal Stem Cell Transplantation
  • Stroke

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