Alzheimer disease risk associated with APOE4 is modified by STH gene polymorphism

Carlo Masullo, Antonio Daniele, Alessandra Bizzarro, Vito Michele Fazio, D. Seripa, M. G. Matera, R. P. D'Andrea, C. Gravina, A. Bizzarro, M. Rinaldi, P. Antuono, D. R. Wekstein, G. Dal Forno, V. M. Fazio

Risultato della ricerca: Contributo in rivistaArticolo in rivista

12 Citazioni (Scopus)

Abstract

The association of the STH gene polymorphism with Alzheimer disease (AD) is debated. In the analysis of two genetically and diagnostically distinct groups of Alzheimer patients from the USA and Italy, the authors did not find an association with the STH polymorphism. However, the APOE-4-associated risk of AD greatly increased if the STH-G allele was also present. The STH-G allele appears to be a risk modifier for AD.
Lingua originaleEnglish
pagine (da-a)1631-1633
Numero di pagine3
RivistaNeurology
Volume62
DOI
Stato di pubblicazionePubblicato - 2004

Keywords

  • Aged
  • Alzheimer Disease
  • Apolipoprotein E4
  • Apolipoproteins E
  • Case-Control Studies
  • DNA Mutational Analysis
  • European Continental Ancestry Group
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Italy
  • Male
  • Polymorphism, Single Nucleotide
  • Risk
  • Risk Factors
  • Tissue Banks
  • Wisconsin
  • tau Proteins

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