Alternative splicing and cell survival: From tissue homeostasis to disease

Claudio Sette, Maria Paola Paronetto, Ilaria Passacantilli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

63 Citazioni (Scopus)

Abstract

Most human genes encode multiple mRNA variants and protein products through alternative splicing of exons and introns during pre-mRNA processing. In this way, alternative splicing amplifies enormously the coding potential of the human genome and represents a powerful evolutionary resource. Nonetheless, the plasticity of its regulation is prone to errors and defective splicing underlies a large number of inherited and sporadic diseases, including cancer. One key cellular process affected by alternative splicing is the programmed cell death or apoptosis. Many apoptotic genes encode for splice variants having opposite roles in cell survival. This regulation modulates cell and tissue homeostasis and is implicated in both developmental and pathological processes. Furthermore, recent evidence has also unveiled splicing-mediated regulation of genes involved in autophagy, another essential process for tissue homeostasis. In this review, we highlight some of the best-known examples of alternative splicing events involved in cell survival. Emphasis is given to the role of this regulation in human cancer and in the response to chemotherapy, providing examples of how alternative splicing of apoptotic genes can be exploited therapeutically.
Lingua originaleEnglish
pagine (da-a)1919-1929
Numero di pagine11
RivistaCell Death and Differentiation
Volume23
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • Alternative Splicing
  • Animals
  • Apoptosis
  • Cell Biology
  • Cell Survival
  • Disease
  • Homeostasis
  • Humans
  • Molecular Biology
  • Neoplasms

Fingerprint Entra nei temi di ricerca di 'Alternative splicing and cell survival: From tissue homeostasis to disease'. Insieme formano una fingerprint unica.

Cita questo