Altered cortico-striatal plasticity and related behavioural parameters in reeler mice. European Journal of Neuroscience, Vol. 24, pp. 2061–2070, 2006

Filippo Biamonte, Maria Cristina Marrone, Silvia Marinelli, Flavio Keller, Sgobio Carmelo Alessio, Martine Ammassari Teule, Bernardi Giorgio, Biagio Nicola Mercuri

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Reelin-deficient mice have been used to investigate the role of this extracellular protein in cortico-striatal plasticity and striatum-related behaviours. Here we show that a repetitive electrical stimulation of the cortico-striatal pathway elicited long-term potentiation (LTP) in homozygous reeler (rl/rl) mice, while causing long-term depression in their wild-type (+/+) littermates. The N-methyl-d-aspartic acid (NMDA) receptor antagonist d-(–)-2 amino-5-phosphonopentanoic acid prevented the induction of LTP in (rl/rl) mice, thus confirming that this form of synaptic plasticity was NMDA receptor-dependent. Interestingly, in the presence of tiagabine, a blocker of γ-aminobutyric acid (GABA) re-uptake system, the probability that (rl/rl) mice showed LTP decreased significantly, thus suggesting an impaired GABAergic transmission in reeler mutants. Consistent with this view, a decreased density of parvalbumin-positive GABAergic striatal interneurons was found in (rl/rl) mice in comparison to (+/+) mice. Finally, compatible with their abnormal striatal function (rl/rl) mice exhibited procedural learning deficits. Our data, showing alterations in cortico-striatal plasticity largely depending on a depressed GABAergic tone, delineate a mechanism whereby the lack of reelin may affect cognitive functions.
Lingua originaleEnglish
pagine (da-a)2061-2070
Numero di pagine10
RivistaEuropean Journal of Neuroscience
Volume24
Stato di pubblicazionePubblicato - 2006

Keywords

  • Inglese

Fingerprint Entra nei temi di ricerca di 'Altered cortico-striatal plasticity and related behavioural parameters in reeler mice. European Journal of Neuroscience, Vol. 24, pp. 2061–2070, 2006'. Insieme formano una fingerprint unica.

Cita questo