We evaluated the presence of HtrA1 in maternal plasma of normal pregnancies and of pregnancies
complicated by preeclampsia (PE) without and with Intrauterine Growth Restriction (IUGR). We
demonstrate that HtrA1 maternal plasma levels show significant different concentrations in first, second
and third trimester of gestation and that HtrA1 concentration increases in maternal plasma of gestations
complicated by PE with IUGR compared with control maternal plasma matched for gestational age. Based
on these data high maternal plasma levels of HtrA1 could be considered as a possible marker of an
occurring IUGR in preeclamptic women.