TY - JOUR
T1 - Alterations in body mass and inflammometabolic indices in
Holstein cows fed different levels of energy and receiving 2,4-thiazolidinedione
AU - Trevisi, Erminio
AU - Bertoni, Giuseppe
AU - Hosseini, Seyed Kianoosh
AU - Tahvildari, Maryam
AU - Alemzadeh Ansari, Mohammad Javad
AU - Nakhjavani, Manouchehr
AU - Esteghamati, Alireza
AU - Lotfi Tokaldany, Masoumeh
PY - 2013
Y1 - 2013
N2 - Overfeeding energy during the dry period increases the incidence of
metabolic disease postpartum. Dry matter intake (DMI), body condition
score (BCS) and blood inflammometabolic markers can serve as reliable
indicator of health, inflammation and liver function. We evaluated
DMI, BCS, metabolism, inflammation, and liver function in response to
level of dietary energy and 2,4-thiazolidinedione (TZD) administration.
Fourteen dry non-pregnant Holstein cows were assigned to treatments
in a randomized block design. All cows were fed a control diet (CON;
NEL = 1.32 Mcal/kg) to meet 100% of NRC requirements for 3 wk,
after which half of the cows were assigned to a moderate-energy diet
(OVE; NEL = 1.54 Mcal/kg) and half of the cows continued on CON for
6 wk. The OVE diet was fed ad libitum and resulted in cows consuming
~180% of NRC. CON cows were fed to consume only to 100% of
NRC. All cows received 4 mg TZD/kg of BW daily starting 2 wk after
the initiation of treatments and for 2 additional wk. The last 2 wk of the
study served as the washout period. BW and BCS were recorded twice a
week, while DMI was recorded daily during the entire study. Blood was
harvested frequently during wk −1 to 6 for measurement of metabolites
and hormones. Data were analyzed using PROC MIXED of SAS. In
OVE compared with CON, the BW, DMI and DMI as a percentage of
BW increased over time (P < 0.001), while BCS remained unchanged.
The concentration of glucose, hydroxybutyrate (BHBA), cholesterol
and aspartate aminotransferase-oxaloacetic transaminase (AST-GOT)
increased (P ≤ 0.04) in OVE, but paraoxonase (PON) decreased (P ≤
0.03) over time compared with CON. Overall concentration of NEFA
and haptoglobin was lower (P < 0.05) in OVE than CON. An improvement
of energy balance status in OVE cows was observed without a
negative effect of TZD on DMI. The changes in AST-GOT and PON
might reflect the effects of OVE on hepatic function. Excess dietary
energy did not enhance inflammation and oxidative stress. In contrast
with previous studies, TZD did not improve insulin sensitivity beyond
what was observed with OVE alone.
AB - Overfeeding energy during the dry period increases the incidence of
metabolic disease postpartum. Dry matter intake (DMI), body condition
score (BCS) and blood inflammometabolic markers can serve as reliable
indicator of health, inflammation and liver function. We evaluated
DMI, BCS, metabolism, inflammation, and liver function in response to
level of dietary energy and 2,4-thiazolidinedione (TZD) administration.
Fourteen dry non-pregnant Holstein cows were assigned to treatments
in a randomized block design. All cows were fed a control diet (CON;
NEL = 1.32 Mcal/kg) to meet 100% of NRC requirements for 3 wk,
after which half of the cows were assigned to a moderate-energy diet
(OVE; NEL = 1.54 Mcal/kg) and half of the cows continued on CON for
6 wk. The OVE diet was fed ad libitum and resulted in cows consuming
~180% of NRC. CON cows were fed to consume only to 100% of
NRC. All cows received 4 mg TZD/kg of BW daily starting 2 wk after
the initiation of treatments and for 2 additional wk. The last 2 wk of the
study served as the washout period. BW and BCS were recorded twice a
week, while DMI was recorded daily during the entire study. Blood was
harvested frequently during wk −1 to 6 for measurement of metabolites
and hormones. Data were analyzed using PROC MIXED of SAS. In
OVE compared with CON, the BW, DMI and DMI as a percentage of
BW increased over time (P < 0.001), while BCS remained unchanged.
The concentration of glucose, hydroxybutyrate (BHBA), cholesterol
and aspartate aminotransferase-oxaloacetic transaminase (AST-GOT)
increased (P ≤ 0.04) in OVE, but paraoxonase (PON) decreased (P ≤
0.03) over time compared with CON. Overall concentration of NEFA
and haptoglobin was lower (P < 0.05) in OVE than CON. An improvement
of energy balance status in OVE cows was observed without a
negative effect of TZD on DMI. The changes in AST-GOT and PON
might reflect the effects of OVE on hepatic function. Excess dietary
energy did not enhance inflammation and oxidative stress. In contrast
with previous studies, TZD did not improve insulin sensitivity beyond
what was observed with OVE alone.
KW - dairy cow
KW - metabolic adaptation
KW - dairy cow
KW - metabolic adaptation
UR - http://hdl.handle.net/10807/53410
M3 - Conference article
VL - 91
SP - 467
EP - 467
JO - Journal Animal Science
JF - Journal Animal Science
T2 - JAM
Y2 - 8 July 2013 through 12 July 2013
ER -