Allogenic Cord Blood Transfusion in Preterm Infants

Luciana Teofili; Patrizia Papacci; Carmen Giannantonio; Maria Bianchi; Caterina Giovanna Valentini; Giovanni Vento

doi:10.1016/j.clp.2023.07.005

Allogenic Cord Blood Transfusion in Preterm Infants

Luciana Teofili^*, Patrizia Papacci, Carmen Giannantonio, Maria Bianchi, Caterina Giovanna Valentini, Giovanni Vento

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

: Repeated red blood cell (RBC) transfusions in preterm neonates cause the progressive displacement of fetal hemoglobin (HbF) by adult hemoglobin. The ensuing increase of oxygen delivery may result at the cellular level in a dangerous condition of hyperoxia, explaining the association between low-HbF levels and retinopathy of prematurity or bronchopulmonary dysplasia. Transfusing preterm neonates with RBC concentrates obtained from allogeneic umbilical blood is a strategy to increase hemoglobin concentration without depleting the physiologic HbF reservoir. This review summarizes the mechanisms underlying a plausible beneficial impact of this strategy and reports clinical experience gathered so far in this field.

Lingua originale	English
pagine (da-a)	881-893
Numero di pagine	13
Rivista	Clinics in Perinatology
Volume	50
DOI	https://doi.org/10.1016/j.clp.2023.07.005
Stato di pubblicazione	Pubblicato - 2023

Keywords

Blood product
Cord blood
Fetal hemoglobin
Oxidative stress
Preterm neonates

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10.1016/j.clp.2023.07.005

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title = "Allogenic Cord Blood Transfusion in Preterm Infants",

abstract = ": Repeated red blood cell (RBC) transfusions in preterm neonates cause the progressive displacement of fetal hemoglobin (HbF) by adult hemoglobin. The ensuing increase of oxygen delivery may result at the cellular level in a dangerous condition of hyperoxia, explaining the association between low-HbF levels and retinopathy of prematurity or bronchopulmonary dysplasia. Transfusing preterm neonates with RBC concentrates obtained from allogeneic umbilical blood is a strategy to increase hemoglobin concentration without depleting the physiologic HbF reservoir. This review summarizes the mechanisms underlying a plausible beneficial impact of this strategy and reports clinical experience gathered so far in this field.",

keywords = "Blood product, Cord blood, Fetal hemoglobin, Oxidative stress, Preterm neonates, Blood product, Cord blood, Fetal hemoglobin, Oxidative stress, Preterm neonates",

author = "Luciana Teofili and Patrizia Papacci and Carmen Giannantonio and Maria Bianchi and {Giovanna Valentini}, Caterina and Giovanni Vento",

year = "2023",

doi = "10.1016/j.clp.2023.07.005",

language = "English",

volume = "50",

pages = "881--893",

journal = "Clinics in Perinatology",

issn = "0095-5108",

publisher = "W.B. Saunders",

}

TY - JOUR

T1 - Allogenic Cord Blood Transfusion in Preterm Infants

AU - Teofili, Luciana

AU - Papacci, Patrizia

AU - Giannantonio, Carmen

AU - Bianchi, Maria

AU - Giovanna Valentini, Caterina

AU - Vento, Giovanni

PY - 2023

Y1 - 2023

N2 - : Repeated red blood cell (RBC) transfusions in preterm neonates cause the progressive displacement of fetal hemoglobin (HbF) by adult hemoglobin. The ensuing increase of oxygen delivery may result at the cellular level in a dangerous condition of hyperoxia, explaining the association between low-HbF levels and retinopathy of prematurity or bronchopulmonary dysplasia. Transfusing preterm neonates with RBC concentrates obtained from allogeneic umbilical blood is a strategy to increase hemoglobin concentration without depleting the physiologic HbF reservoir. This review summarizes the mechanisms underlying a plausible beneficial impact of this strategy and reports clinical experience gathered so far in this field.

AB - : Repeated red blood cell (RBC) transfusions in preterm neonates cause the progressive displacement of fetal hemoglobin (HbF) by adult hemoglobin. The ensuing increase of oxygen delivery may result at the cellular level in a dangerous condition of hyperoxia, explaining the association between low-HbF levels and retinopathy of prematurity or bronchopulmonary dysplasia. Transfusing preterm neonates with RBC concentrates obtained from allogeneic umbilical blood is a strategy to increase hemoglobin concentration without depleting the physiologic HbF reservoir. This review summarizes the mechanisms underlying a plausible beneficial impact of this strategy and reports clinical experience gathered so far in this field.

KW - Blood product

KW - Cord blood

KW - Fetal hemoglobin

KW - Oxidative stress

KW - Preterm neonates

KW - Blood product

KW - Cord blood

KW - Fetal hemoglobin

KW - Oxidative stress

KW - Preterm neonates

UR - http://hdl.handle.net/10807/274458

U2 - 10.1016/j.clp.2023.07.005

DO - 10.1016/j.clp.2023.07.005

M3 - Article

SN - 0095-5108

VL - 50

SP - 881

EP - 893

JO - Clinics in Perinatology

JF - Clinics in Perinatology

ER -

Allogenic Cord Blood Transfusion in Preterm Infants

Abstract

Keywords

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