TY - JOUR
T1 - Allogeneic hematopoietic stem cell transplantation may restore gluten tolerance in patients with celiac disease
AU - Ciccocioppo, Rachele
AU - Bernardo, Maria Ester
AU - Russo, Maria Luisa
AU - Vanoli, Alessandro
AU - Franco, Carla
AU - Martinetti, Myriam
AU - Catenacci, Laura
AU - Giorgiani, Giovanna
AU - Zecca, Marco
AU - Piralla, Antonio
AU - Baldanti, Fausto
AU - Locatelli, Franco
AU - Corazza, Gino Roberto
PY - 2013
Y1 - 2013
N2 - We report on 2 patients affected by both celiac disease (CD) and beta-thalassemia major who underwent successful myeloablative allogeneic hematopoietic stem cell transplantation (HSCT) for the latter condition. After HSCT, the introduction of a gluten-containing diet did not cause the reappearance of clinical, serological, and histological markers of CD in up to 5 years of follow-up. After transplantation, in both patients, dendritic cells and regulatory FoxP3(+)T cells showed a recovery of normal values and no proliferative T-cell response upon gliadin stimulation was found. These data suggest that allogeneic HSCT may lead to induction of gluten tolerance in patients with CD.
AB - We report on 2 patients affected by both celiac disease (CD) and beta-thalassemia major who underwent successful myeloablative allogeneic hematopoietic stem cell transplantation (HSCT) for the latter condition. After HSCT, the introduction of a gluten-containing diet did not cause the reappearance of clinical, serological, and histological markers of CD in up to 5 years of follow-up. After transplantation, in both patients, dendritic cells and regulatory FoxP3(+)T cells showed a recovery of normal values and no proliferative T-cell response upon gliadin stimulation was found. These data suggest that allogeneic HSCT may lead to induction of gluten tolerance in patients with CD.
KW - celiac disease
KW - gluten
KW - hematopoietic stem cell transplantation
KW - tolerance
KW - celiac disease
KW - gluten
KW - hematopoietic stem cell transplantation
KW - tolerance
UR - http://hdl.handle.net/10807/244274
U2 - 10.1097/MPG.0b013e318276a6a7
DO - 10.1097/MPG.0b013e318276a6a7
M3 - Article
SN - 0277-2116
VL - 56
SP - 422
EP - 427
JO - Journal of Pediatric Gastroenterology and Nutrition
JF - Journal of Pediatric Gastroenterology and Nutrition
ER -