TY - JOUR
T1 - Allogeneic hematopoietic stem cell transplantation for Philadelphia-positive acute lymphoblastic leukemia in children and adolescents: a retrospective multicenter study of the Italian Association of Pediatric Hematology and Oncology (AIEOP)
AU - Fagioli, Franca
AU - Zecca, Marco
AU - Rognoni, Carla
AU - Lanino, Edoardo
AU - Balduzzi, Adriana
AU - Berger, Massimo
AU - Messina, Chiara
AU - Favre, Claudio
AU - Rabusin, Marco
AU - Lo Nigro, Luca
AU - Masetti, Riccardo
AU - Prete, Arcangelo
AU - Locatelli, Franco
PY - 2012
Y1 - 2012
N2 - Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL) still represents a major challenge. We report the experience of the Italian Association of Pediatric Hematology and Oncology (AIEOP) with allogeneic hematopoietic stem cell transplantation (HSCT) in children with Ph+ ALL from 1990 to 2008. Sixty-nine patients received HSCT from either a related (37, 54%) or an unrelated (32,46%) donor. Twenty-five patients (36%) underwent transplantation before 2000 and 44 (64%) after 2000. Twenty-three patients (33%) received lmatinib mesylate treatment before HSCT and seven (10%) after HSCT. After a median follow-up of 56 months, the overall survival (OS) probability was 51% (95% confidence interval [Cl], 38-63), the leukemia-free survival (LFS) was 47% (95% CI, 34-59), transplantation-related mortality (TRM) was 17% (95% CI, 10-30), and relapse incidence (RI) was 36% (95% CI, 26-50). Transplantation in first complete remission, female gender, and lower WBC count at diagnosis were associated with a better LFS in both univariate and multivariate analyses. Patients with p210 transcript had a trend for a worse prognosis compared with those who had the p190 transcript. Our series confirms the role of HSCT in the eradication of Ph+ ALL. Early HSCT is recommended once morphologic remission is obtained. Biol Blood Marrow Transplant 18: 852-860 (2012) (C) 2012 American Society for Blood and Marrow Transplantation
AB - Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL) still represents a major challenge. We report the experience of the Italian Association of Pediatric Hematology and Oncology (AIEOP) with allogeneic hematopoietic stem cell transplantation (HSCT) in children with Ph+ ALL from 1990 to 2008. Sixty-nine patients received HSCT from either a related (37, 54%) or an unrelated (32,46%) donor. Twenty-five patients (36%) underwent transplantation before 2000 and 44 (64%) after 2000. Twenty-three patients (33%) received lmatinib mesylate treatment before HSCT and seven (10%) after HSCT. After a median follow-up of 56 months, the overall survival (OS) probability was 51% (95% confidence interval [Cl], 38-63), the leukemia-free survival (LFS) was 47% (95% CI, 34-59), transplantation-related mortality (TRM) was 17% (95% CI, 10-30), and relapse incidence (RI) was 36% (95% CI, 26-50). Transplantation in first complete remission, female gender, and lower WBC count at diagnosis were associated with a better LFS in both univariate and multivariate analyses. Patients with p210 transcript had a trend for a worse prognosis compared with those who had the p190 transcript. Our series confirms the role of HSCT in the eradication of Ph+ ALL. Early HSCT is recommended once morphologic remission is obtained. Biol Blood Marrow Transplant 18: 852-860 (2012) (C) 2012 American Society for Blood and Marrow Transplantation
KW - Allogeneic stem cell transplantation
KW - Children
KW - Philadelphia-positive acute lymphoblastic leukemia
KW - Allogeneic stem cell transplantation
KW - Children
KW - Philadelphia-positive acute lymphoblastic leukemia
UR - http://hdl.handle.net/10807/245638
U2 - 10.1016/j.bbmt.2011.10.015
DO - 10.1016/j.bbmt.2011.10.015
M3 - Article
SN - 1523-6536
VL - 18
SP - 852
EP - 860
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
ER -