Allergic inflammation: role of cytokines with special emphasis on IL-4

Franco Pandolfi, A Saggini, G Maccauro, D Tripodi, Ma De Lutiis, F Conti, P Felaco, M Fulcheri, R Galzio, A Caraffa, P Antinolfi, M Felaco, G Sabatino, G Neri, Yb Shaik Dasthagirisaheb

Risultato della ricerca: Contributo in rivistaArticolo in rivista

23 Citazioni (Scopus)

Abstract

This review examines recent articles on the relationship of cytokines to allergy and inflammation with particular emphasis on interleukin (IL)-4. The objective of this article is therefore to review published studies to identify cytokines consistently involved in allergic inflammation. Proinflammatory cytokines, including IL-4, IL-5, IL-13 and GM-CSF along with TNF-alpha play a role in allergen-induced airway leukocyte recruitment and these cytokines can be generated by T mast cells and other cells. In addition, IL-9, IL-25, IL-33, IL-17, IL-27 and IFN-gamma are deeply involved in the regulation of asthma. Blocking the effect of these proinflammatory cytokines might provide new therapeutic approaches for the control of allergy and inflammation.
Lingua originaleEnglish
pagine (da-a)305-311
Numero di pagine7
RivistaInternational Journal of Immunopathology and Pharmacology
Volume24
Stato di pubblicazionePubblicato - 2011

Keywords

  • Animals
  • Cytokines
  • Humans
  • Hypersensitivity
  • Inflammation
  • Inflammation Mediators
  • Interleukin-4
  • Signal Transduction

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