Alcohol-related Liver Disease and sepsis

G. A. Vassallo, Tommaso Dionisi, Claudia Tarli, G. Augello, A. Mirijello, Antonio Mirijello, S. D.E. Cosmo, Antonio Gasbarrini, Giovanni Addolorato

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Sepsis is one of the most common complications and causes of death in patients with Alcohol-related Liver Disease. This narrative review will focus on several aspects of sepsis in the context of Alcohol-related Liver Disease. The pathophysiology of the increased susceptibility to infections consists mainly of impaired innate and adaptive immunity, changes in gut microbiota with consequent gut translocation of bacteria due to both alcohol abuse and the underlying liver disease. The diagnosis of sepsis in the context of Alcohol-related Liver Disease is challenging. Moreover, the use of classical acute-phase serum proteins (e.g., C-reactive protein and procalcitonin) has several limitations in this setting. The early administration of an adequate antibiotic treatment is pivotal. Finally, measures of infection control and prevention are needed because the prognosis of sepsis in patients affected by Alcohol-related Liver Disease is poor.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaEuropean Review for Medical and Pharmacological Sciences
DOI
Stato di pubblicazionePubblicato - 2021

Keywords

  • AUD

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